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Pregled bibliografske jedinice broj: 442179

Apoptosis in psoriasis


Kaštelan, Marija; Prpić-Massari, Larisa; Brajac, Ines
Apoptosis in psoriasis // Acta dermatovenerologica Croatica, 17 (2009), 182-186 (međunarodna recenzija, pregledni rad, znanstveni)


CROSBI ID: 442179 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Apoptosis in psoriasis

Autori
Kaštelan, Marija ; Prpić-Massari, Larisa ; Brajac, Ines

Izvornik
Acta dermatovenerologica Croatica (1330-027X) 17 (2009); 182-186

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Apoptosis; Bcl-2 family proteins; Fas/FasL; Perforin; Psoriasis
(apoptosis; Bcl-2 family proteins; Fas/FasL; perforin; psoriasis)

Sažetak
Apoptosis is a process of programmed cell death that maintains the homeostasis of the skin. Apoptotic cell death regulates keratinocyte proliferation and formation of stratum corneum as well. The process by which keratinocytes undergo apoptosis is a multistep program mediated by binding of specific death ligands to death receptors or by the release of effectors cell granules. Dysfunctional apoptosis has an important role in the development of several skin diseases. Psoriasis is a common chronic inflammatory skin disease characterized by hyperproliferation with incomplete differentiation of epidermal keratinocytes and decreased keratinocyte apoptosis. Psoriatic keratinocytes possess an enhanced ability to resist apoptosis what might be one of the key pathogenetic mechanisms in psoriasis. In addition, psoriasis is nowadays also recognized as the most prevalent autoimmune disease resulting from aberrant activation of both, innate and adaptive immunity. However, the role of cell cytotoxicity mediated by cytotoxic CD8+ T cells (CTLs) and NK cells in psoriasis is as yet unclear. Here, we shall review the role of different apoptotic pathways in psoriasis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
062-0620239-0197 - Imunološki mehanizmi u patogenezi psorijaze (Kaštelan, Marija, MZOS ) ( POIROT)
062-0620239-0199 - Uloga neurogene upale i psihičkih čimbenika u patogenezi psorijaze (Brajac, Ines, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka

Profili:

Avatar Url Larisa Prpić Massari (autor)

Avatar Url Ines Brajac (autor)

Avatar Url Marija Kaštelan (autor)

Citiraj ovu publikaciju:

Kaštelan, Marija; Prpić-Massari, Larisa; Brajac, Ines
Apoptosis in psoriasis // Acta dermatovenerologica Croatica, 17 (2009), 182-186 (međunarodna recenzija, pregledni rad, znanstveni)
Kaštelan, M., Prpić-Massari, L. & Brajac, I. (2009) Apoptosis in psoriasis. Acta dermatovenerologica Croatica, 17, 182-186.
@article{article, year = {2009}, pages = {182-186}, keywords = {Apoptosis, Bcl-2 family proteins, Fas/FasL, Perforin, Psoriasis}, journal = {Acta dermatovenerologica Croatica}, volume = {17}, issn = {1330-027X}, title = {Apoptosis in psoriasis}, keyword = {Apoptosis, Bcl-2 family proteins, Fas/FasL, Perforin, Psoriasis} }
@article{article, year = {2009}, pages = {182-186}, keywords = {apoptosis, Bcl-2 family proteins, Fas/FasL, perforin, psoriasis}, journal = {Acta dermatovenerologica Croatica}, volume = {17}, issn = {1330-027X}, title = {Apoptosis in psoriasis}, keyword = {apoptosis, Bcl-2 family proteins, Fas/FasL, perforin, psoriasis} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka::


  • MEDLINE





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