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PPARγ – A New Concept Of Treatment?

Peroxisome proliferator-activated receptors (PPARs)are ligand-activated transcription factors belonging to the nuclear receptor superfamily, which also includes the steroid and thyroid hormone receptors. PPARs modulate genes that regulate lipid and glucose metabolism and control many cellular and metabolic processes. Three isotypes called PPARα, PPAR β/δ and PPARγ have been identified. Their activity can be modulated by drugs such as fibrates and thiazolidinediones. Understanding the biology and identifying small molecule modulators of the PPARs is an active area of research and may impact chronic diseases such as type 2 diabetes, dyslipidemia, atherosclerosis and the metabolic syndrome.

peroxisome proliferator-activated receptors (PPARs); nuclear receptor; thiazolidinediones; diabetes mellitus

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