engleski

First Zn(II) Bowl-Complexes Modeling the Tris(Histidine) Metallo-Site of Enzymes

The bowl-shaped resorcin[4]arene-based ligand 7 was prepared through a seven-step synthetic procedure. The ligand 7, bearing three imidazol coordination arms, represents a structural biomimetic model of the ubiquitous trihistidine coordination core in the active sites of many mononuclear metalloenzymes. The - CH2-O-CH2- linkers connecting the imidazol units with the upper rim of the bowl-shaped resorcinarene cavity have been designed to allow all three imidazoles to simultaneously bind a metal ion, and, at the same time, to favor a cis-coordination of two exchangeable external ligands completing the coordination sphere of the metal ion. The corresponding two mononuclear ZnII complexes (perchlorato- and acetato-complexes) were prepared and shown to be capable of the selective guest binding and exchange at both endo and exo positions relative to the bowl-shaped cavity.

resorcin[4]arene •biomimetic complexes• zinc • hostguest

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