Successfulness of two pharmacological strategies for conversions of recent-onset atrial fibrillation and perspectives of local drug delivery (CROSBI ID 557991)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa
Podaci o odgovornosti
Miličević, Goran ; Strinić, Dean ; Gavranović, Željka ; Udiljak, Nikola ; Bakula, Miro
engleski
Successfulness of two pharmacological strategies for conversions of recent-onset atrial fibrillation and perspectives of local drug delivery
Introduction. Pharmacological conversion of recent-onset atrial fibrillation is important practical issue. Related to question of the ESC WG on Cardiovascular Pharmacology and Drug Therapy ‘how to best achieve cardioversion’, we analyzed successfulness of a single drug and sequential drug administration strategies. Furthermore, we tried to enhance the review with an idea on increasing the efficacy of conversion by local delivery of drugs. Methods. A systematic review of controlled trials, published in indexed journals, with antiarrhythmic drugs (of a class III, IC and IA, and atrial-selective) was performed. Eligible studies had to be randomized, controlled, parallel-designed, human trials that prove efficacy of pharmacological cardioversion of recent-onset atrial fibrillation. Results. High diversity in conversion rate of a single antiarrhythmic drug administration is shown, depending on drug dosage and time of its application. Sequential drug administration showed high success rate, but higher time consumption. Conclusion. Atrial-selective drugs have rapid onset of action, but sequential administration of older antiarrhythmic drugs shows excellent success rate. To enhance short-term success rate, local delivery of atrial-selective drugs may be needed. Possible models are proposed.
Atrial; Fibrillation; pharmacology; conversion; therapy
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Podaci o prilogu
54-54.
2009.
objavljeno
Podaci o matičnoj publikaciji
6th Global CardioVascular Clinical Trialists Forum Final Program & Abstracts Book
Zannad, Faiez ; Pitt, Bertram
Pariz:
Podaci o skupu
6th Global CardioVascular Clinical Trialists Forum
poster
03.12.2009-05.12.2009
Pariz, Francuska