Napredna pretraga

Pregled bibliografske jedinice broj: 440978

Single-nucleotide polymophisms in genes encoding toll-like receptor-2, -3, -4, and 9 in case-control study with breast cancer


Etokebe, Godfrey Essien; Knežević, Jelena; Petričević, Branka; Pavelić, Jasminka; Vrbanec, Damir; Dembić, Zlatko
Single-nucleotide polymophisms in genes encoding toll-like receptor-2, -3, -4, and 9 in case-control study with breast cancer // Genetic Testing and Molecular Biomarkers, 13 (2009), 6; 729-734 (međunarodna recenzija, članak, znanstveni)


Naslov
Single-nucleotide polymophisms in genes encoding toll-like receptor-2, -3, -4, and 9 in case-control study with breast cancer

Autori
Etokebe, Godfrey Essien ; Knežević, Jelena ; Petričević, Branka ; Pavelić, Jasminka ; Vrbanec, Damir ; Dembić, Zlatko

Izvornik
Genetic Testing and Molecular Biomarkers (1945-0265) 13 (2009), 6; 729-734

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Breast cancer; genetics; case-control; TLR2; TLR3; TLR4; TLR9

Sažetak
Genetic susceptibility to cancer is multifactorial, and it is known that impairment of the immune system could contribute to risk for getting cancer. Aim of the Study: Single-nucleotide polymorphisms (SNPs) of Toll-like receptor (TLR) 2, TLR3, TLR4, and TLR9 genes, which are important for innate immunity, were analyzed for the association with breast cancer. The SNPs comprised TLR2 (c.597T>C), TLR2 (c.1350T>C), TLR3 (c.1377C>T), TLR4 (c.896A>G), and TLR9 (c.1635A>G). The allelic and genotypic frequencies of these TLR SNPs were compared between patients (n¼130) and controls (n¼101) in a case–control study from Croatia. TLR SNPs were not significantly different. From the population genetics viewpoint, we found that a hypomorphic variant of TLR4 (p.Asp299Gly) allele has no specific allelic frequency (8.4%) in the Croatian population (n¼496) compared to other Caucasians (6.5–10%). These results suggest that polymorphisms in tested TLR genes are not likely to be associated with increased risk for developing breast cancer.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2394 - Gensko liječenje tumora djelovanjem na molekule imunološkog sustava (Jasminka Pavelić, )
108-1080058-0046 - KARCINOM DOJKE-MOLEKULARNE,GENETSKE I KLINIČKE KARAKTERISTIKE (Damir Vrbanec, )

Ustanove
Klinika za dijabetes, endokrinologiju i bolesti metabolizma Vuk Vrhovac

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • EMBASE (Excerpta Medica)