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Pregled bibliografske jedinice broj: 440730

Endomorphine-suppressed nitric oxide release from mice peritoneal macrophages


Balog, Tihomir; Šarić, Ana; Sobočanec, Sandra; Kušić, Borka; Marotti, Tatjana
Endomorphine-suppressed nitric oxide release from mice peritoneal macrophages // Neuropeptides, 44 (2010), 1; 25-29 doi:10.1016 (međunarodna recenzija, članak, znanstveni)


Naslov
Endomorphine-suppressed nitric oxide release from mice peritoneal macrophages

Autori
Balog, Tihomir ; Šarić, Ana ; Sobočanec, Sandra ; Kušić, Borka ; Marotti, Tatjana

Izvornik
Neuropeptides (0143-4179) 44 (2010), 1; 25-29

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Endomorphin 1; endomorphin 2; nitirc oxide; peritoneal macrophages; Interleukin-1

Sažetak
Endomorphins are newly discovered l-opioid receptor selective immunocompetent opioid peptides. Endomorphin 1 is predominantly distributed in brain, while endomorphin 2 is widely allocated in the spinal cord. Lately, endomorphins have been investigated as modulators of reactive oxygen and nitrogen species. Nitric oxide is short lived radical involved in various biological processes such as regulation of blood vessel contraction, inflammation, neurotransmission and apoptosis. The aim of this work was to investigate the in vivo effects of endomorphins on nitric oxide release and NOS 2 isoenzyme upregulation in mice peritoneal macrophages additionally challenged ex vivo with lipopolysaccharide. The results showed that endomorphin 1 or endomorphin 2 in vitro did not change NO release from peritoneal mouse macrophages during a 48 h incubation period. On the other hand in vivo endomorphins had suppressive effect on NO release as well as on NOS 2 and IL-1 protein concentration. The most of suppressive effect in vivo of both endomorphins was blocked with 30 min pretreatment with l-receptor selective antagonist b-FNA, which proved involvement of opioid receptor pathway in suppressive effects of endomorphins.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-1647 - Sustav citokroma P450 i pojava tumora u starenju i oksidacijskom stresu (Tihomir Balog, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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