engleski

The interactions of bis-phenanthridinium – nucleobase conjugates with nucleotides: adenine conjugate recognizes UMP in aqueous medium

Among series of novel bis-phenanthridinium – nucleobase conjugates, the adenine derivative revealed high (logKs = 6.9 M-1) and selective affinity toward complementary nucleotide (UMP), accompanied by specific change in the UV/Vis spectrum of phenanthridine subunits, differing significantly from changes caused by addition of other nucleotides. High stability and selectivity of adenine-conjugate/UMP non-covalent complex is, according to the molecular modelling studies, correlated to the number of inter- and intramolecular aromatic stacking interactions between phenanthridinium subunits, covalently attached adenine and added UMP, while the selectivity of adenine-conjugate toward UMP in respect to other nucleotides is most likely the consequence of additional hydrogen bonding between UMP and adenine.

nucleotide ; bis-phenanthridine ; recognition ; spectroscopy

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