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Pregled bibliografske jedinice broj: 439501

Effects of α-Melanocortin Enantiomers on Acetaminophen-Induced Hepatotoxicity in CBA Mice


Turčić, Petra; Bradamante, Mirna; Houra, Karlo; Štambuk, Nikola; Kelava, Tomislav; Konjevoda, Paško; Kazazić, Saša; Vikić-Topić, Dražen; Pokrić, Biserka
Effects of α-Melanocortin Enantiomers on Acetaminophen-Induced Hepatotoxicity in CBA Mice // Molecules, 14 (2009), 12; 5017-5026 doi:10.3390/molecules14125017 (međunarodna recenzija, članak, znanstveni)


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Naslov
Effects of α-Melanocortin Enantiomers on Acetaminophen-Induced Hepatotoxicity in CBA Mice

Autori
Turčić, Petra ; Bradamante, Mirna ; Houra, Karlo ; Štambuk, Nikola ; Kelava, Tomislav ; Konjevoda, Paško ; Kazazić, Saša ; Vikić-Topić, Dražen ; Pokrić, Biserka

Izvornik
Molecules (1420-3049) 14 (2009), 12; 5017-5026

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
enantiomer ; α-MSH ; hepatoprotection ; hepatotoxicity ; antibody ; CD spectroscopy

Sažetak
Proteins and peptides in mammals are based exclusively on L-amino acids. Recent investigations show that D-amino acids exhibit physiological effects in vivo, despite of their very small quantities. We have investigated the hepatoprotective effects of the L and D-enantiomers of α-melanocortin peptide (α-MSH). The results showed that peptide enantiomerism is related to the protective effects of melanocortin peptides in vivo. L-α-MSH exhibited potent hepatoprotective effect in the experimental model of acetaminophen induced hepatotoxicity in male CBA mice, while its D-mirror image was inefficient. Furthermore, the antibody to the L-peptide did not recognize the D-structure. The results indicate that the opposite peptide configuration may be used to modulate its function and metabolism in vivo and in vitro.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
098-0982915-2945 - Spektroskopija, kemijska svojstva i reakcije biološki aktivnih molekula (Kovač, Branka, MZOS ) ( POIROT)
098-0982929-2524 - Modeliranje bioaktivnih molekula i ispitivanje njihovih svojstava i učinka (Štambuk, Nikola, MZOS ) ( POIROT)
218-0000000-3657 - Maligni epidermalni kožni tumori u Hrvatskoj (Lipozenčić, Jasna, MZOS ) ( POIROT)
108-0000000-0328 - Uloga proupalnih citokina i prostaglandina u akutnom oštećenju jetre

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Klinički bolnički centar Zagreb

Citiraj ovu publikaciju

Turčić, Petra; Bradamante, Mirna; Houra, Karlo; Štambuk, Nikola; Kelava, Tomislav; Konjevoda, Paško; Kazazić, Saša; Vikić-Topić, Dražen; Pokrić, Biserka
Effects of α-Melanocortin Enantiomers on Acetaminophen-Induced Hepatotoxicity in CBA Mice // Molecules, 14 (2009), 12; 5017-5026 doi:10.3390/molecules14125017 (međunarodna recenzija, članak, znanstveni)
Turčić, P., Bradamante, M., Houra, K., Štambuk, N., Kelava, T., Konjevoda, P., Kazazić, S., Vikić-Topić, D. & Pokrić, B. (2009) Effects of α-Melanocortin Enantiomers on Acetaminophen-Induced Hepatotoxicity in CBA Mice. Molecules, 14 (12), 5017-5026 doi:10.3390/molecules14125017.
@article{article, year = {2009}, pages = {5017-5026}, DOI = {10.3390/molecules14125017}, keywords = {enantiomer, α-MSH, hepatoprotection, hepatotoxicity, antibody, CD spectroscopy}, journal = {Molecules}, doi = {10.3390/molecules14125017}, volume = {14}, number = {12}, issn = {1420-3049}, title = {Effects of α-Melanocortin Enantiomers on Acetaminophen-Induced Hepatotoxicity in CBA Mice}, keyword = {enantiomer, α-MSH, hepatoprotection, hepatotoxicity, antibody, CD spectroscopy} }
@article{article, year = {2009}, pages = {5017-5026}, DOI = {10.3390/molecules14125017}, keywords = {enantiomer, α-MSH, hepatoprotection, hepatotoxicity, antibody, CD spectroscopy}, journal = {Molecules}, doi = {10.3390/molecules14125017}, volume = {14}, number = {12}, issn = {1420-3049}, title = {Effects of α-Melanocortin Enantiomers on Acetaminophen-Induced Hepatotoxicity in CBA Mice}, keyword = {enantiomer, α-MSH, hepatoprotection, hepatotoxicity, antibody, CD spectroscopy} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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