engleski

Synthesis, Characterization and in Vitro Pharmacology of Novel Pregabalin Derivatives

A series of novel pregabalin derivatives were synthesized starting from N-protected pregabalin, different amino sugars, adamantylamine, serotonin and tryptamine. Gabapentin receptor binding assay study showed the one among them, the serotonin-pregabalin adduct 17, posseses a promissing activity (Ki =11 µM).

pregabalin ; gabapentin ; binding affinity

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