engleski

Novel /1, 4/thiazino/4, 3, 2-dg/purines from allylhypoxanthine derivative

The allylation of hypoxanthine by silyl method afforded 3, 7-diallyl-(1), 7-allyl-(2), and 3-allyl-(3) hypoxanthine. The bromination of 7-allyl-4-thiohypoxantine (14) in CH2Cl2, the latter being prepared by thiation of (2), proceeded to the hitherto unknown 5-bomomehhyl-4, 5-dihidro(1, 4)thiazino(4, 3, 2-gh)purine hydrobromide(15) which under basic conditions transformed into 5-methylene-4, 5-dihidro(1, 4)thiazino(4, 3, 2-gh)purine(16).

purines; virostatics

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