engleski

Neuroimmunomodulation by regional and general anaesthesia

Considerable in-vitro data and in-vivo animal studies suggest that three factors associated with cancer surgery impair cellular immunity: the stress response to tissue injury, general anaesthesia and opioid analgesia. Regional analgesia decreases the neuroendocrine stress response to surgical tissue injury, eliminates or reduces the need for general anaesthesia and minimises opioid requirement. Thus cancer recurrence is lower after surgery with regional anaesthesia/ analgesia than after surgery with general anaesthesia and opioid analgesia.

immunology; stress; surgical injury

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