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Pregled bibliografske jedinice broj: 437558

Comparison of the Effects of Low Intra- Abdominal Pressure and Pentoxifylline on Oxidative Stress during CO2 Pneumoperitoneum in Rabbits


Nesek Adam, Višnja; Vnuk, Dražen; Rašić, Žarko; Rumenjak, Vlatko; Kos, Josip; Krstonijević, Zoran
Comparison of the Effects of Low Intra- Abdominal Pressure and Pentoxifylline on Oxidative Stress during CO2 Pneumoperitoneum in Rabbits // European surgical research, 43 (2009), 4; 330-337 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 437558 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Comparison of the Effects of Low Intra- Abdominal Pressure and Pentoxifylline on Oxidative Stress during CO2 Pneumoperitoneum in Rabbits

Autori
Nesek Adam, Višnja ; Vnuk, Dražen ; Rašić, Žarko ; Rumenjak, Vlatko ; Kos, Josip ; Krstonijević, Zoran

Izvornik
European surgical research (0014-312X) 43 (2009), 4; 330-337

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CO2 pneumoperitoneum ; ischemia/reperfusion injuri ; oxidative stress ; pentoxifyline
(CO2 pneumoperitoneum ; ischemia/reperfusion injuri ; oxidative stress ; pentoxifylline)

Sažetak
The aim of this study was to investigate the effect of low-pressure pneumoperitoneum and pentoxifylline, a methylxanthine derivative, in the prevention of injury caused by free oxygen radicals generated during CO2 pneumoperitoneum. Twenty-eight rabbits were allocated randomly to 4 groups. Control group rabbits (group 1) were subjected to anesthesia for 60 min ; group 2 and 3 animals were subjected to a CO2 pneumoperitoneum (15 or 7 mm Hg) ; and group 4 rabbits received 50 mg/kg pentoxifylline, followed by a 15-mm-Hg pneumoperitoneum. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), lipid hydroperoxide, glutathione reductase and total antioxidant status were measured. Compared with group 1, a significant increase in lipid hydroperoxide levels at the end of the pneumoperitoneum and 30 min after deflation and a significant decrease in total antioxidant status 24 h after deflation were recorded in group 2. In addition, a significant increase was observed in ALT, AST and LDH levels. These changes were attenuated by low- pressure pneumoperitoneum, whereas pentoxifylline pretreatment appeared to attenuate only transaminase levels. Low- pressure pneumoperitoneum could attenuate ischemia/reperfusion injury induced by CO2 pneumoperitoneum in a rabbit model whereas pentoxifylline pretreatment appeared to attenuate only transaminase levels. Pentoxifylline did not prevent the development of oxidative stress.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
053-0532053-2051 - Regeneracija koštanog tkiva primjenom slobodnog grafta omentuma (Kos, Josip, MZOS ) ( POIROT)

Ustanove:
Veterinarski fakultet, Zagreb,
Sveučilište Libertas

Citiraj ovu publikaciju

Nesek Adam, Višnja; Vnuk, Dražen; Rašić, Žarko; Rumenjak, Vlatko; Kos, Josip; Krstonijević, Zoran
Comparison of the Effects of Low Intra- Abdominal Pressure and Pentoxifylline on Oxidative Stress during CO2 Pneumoperitoneum in Rabbits // European surgical research, 43 (2009), 4; 330-337 (međunarodna recenzija, članak, znanstveni)
Nesek Adam, V., Vnuk, D., Rašić, Ž., Rumenjak, V., Kos, J. & Krstonijević, Z. (2009) Comparison of the Effects of Low Intra- Abdominal Pressure and Pentoxifylline on Oxidative Stress during CO2 Pneumoperitoneum in Rabbits. European surgical research, 43 (4), 330-337.
@article{article, year = {2009}, pages = {330-337}, keywords = {CO2 pneumoperitoneum, ischemia/reperfusion injuri, oxidative stress, pentoxifyline}, journal = {European surgical research}, volume = {43}, number = {4}, issn = {0014-312X}, title = {Comparison of the Effects of Low Intra- Abdominal Pressure and Pentoxifylline on Oxidative Stress during CO2 Pneumoperitoneum in Rabbits}, keyword = {CO2 pneumoperitoneum, ischemia/reperfusion injuri, oxidative stress, pentoxifyline} }
@article{article, year = {2009}, pages = {330-337}, keywords = {CO2 pneumoperitoneum, ischemia/reperfusion injuri, oxidative stress, pentoxifylline}, journal = {European surgical research}, volume = {43}, number = {4}, issn = {0014-312X}, title = {Comparison of the Effects of Low Intra- Abdominal Pressure and Pentoxifylline on Oxidative Stress during CO2 Pneumoperitoneum in Rabbits}, keyword = {CO2 pneumoperitoneum, ischemia/reperfusion injuri, oxidative stress, pentoxifylline} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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