C282Y, H63D and S65C mutations of the hemochromatosis gene (HFE) in patients with alcoholic cirrhosis (CROSBI ID 557302)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Starčević Čizmarević, Nada ; Stepec, Srećko ; Ristić, Smiljana ; Milić, Sandra ; Brajenović-Milić, Bojana ; Štimac, Davor ; Kapović, Miljenko ; Peterlin, Borut
engleski
C282Y, H63D and S65C mutations of the hemochromatosis gene (HFE) in patients with alcoholic cirrhosis
We have investigated the contribution of genetic polymorphisms in the hemochromatosis gene to susceptibility for alcoholic liver disease in Croatian and Slovenian patients. The genotypes of alcoholics with and without cirrhosis, and healthy controls for the polymorphisms C282Y, H63D, and S65C suggested that C282Y and S65C mutations were not associated to the risk of developing alcoholic cirrhosis in our populations, while the frequency of H63D heterozygotes was significantly higher (P=0.0019) in patients with alcoholic cirrhosis (31.98%) than in healthy controls (19.14%).
alcoholic cirrhosis; hemochromatosis; HFE gene mutations
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Podaci o prilogu
2005.
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objavljeno
Podaci o matičnoj publikaciji
European journal of human genetics
Prag:
1018-4813
Podaci o skupu
European Human genetics Conference
poster
07.05.2005-10.05.2005
Prag, Češka Republika