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Pregled bibliografske jedinice broj: 437342

IL-2 -330 T/G SNP and serum values - potential new tumor markers in neuroendocrine tumors of the gastrointestinal tract and pancreas (GEP-NETs)


Cigrovski Berković, Maja; Jokić, Mladen; Marout, Jasminka; Radošević, Senka; Zjačić-Rotkvić, Vanja; Kapitanović, Sanja
IL-2 -330 T/G SNP and serum values - potential new tumor markers in neuroendocrine tumors of the gastrointestinal tract and pancreas (GEP-NETs) // Journal of molecular medicine, 88 (2010), 4; 423-429 doi:10.1007/s00109-009-0581-x (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 437342 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
IL-2 -330 T/G SNP and serum values - potential new tumor markers in neuroendocrine tumors of the gastrointestinal tract and pancreas (GEP-NETs)

Autori
Cigrovski Berković, Maja ; Jokić, Mladen ; Marout, Jasminka ; Radošević, Senka ; Zjačić-Rotkvić, Vanja ; Kapitanović, Sanja

Izvornik
Journal of molecular medicine (0946-2716) 88 (2010), 4; 423-429

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
IL2 ; regulatory polymorphism ; GEP-NET ; susceptibility ; tumor marker

Sažetak
Cytokines participate in tumorigenesis of gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Single nucleotide polymorphisms (SNPs) in cytokine genes influence expression of proteins and are evaluated in cancer susceptibility. Aim of this study was to evaluate IL-2 -330T/G SNP and susceptibility to GEP-NETs, and analyze the correlation between G-allele and IL-2 serum values in GEP-NET patients. Moreover we assessed the value of IL-2 as a tumor serum marker. IL-2 -330T/G SNP was examined in 101 patients and 150 healthy volunteers, and IL-2 serum levels in patients and 20 controls. Patients’ IL-2 serum levels were compared to IL-2 -330T/G genotypes and tumor functional status, and finally with known markers such as chromogranin A (CgA) and 5-hydroxyindolacetic acid (5-HIAA). There was a significant difference in genotype distribution of the IL-2 -330 polymorphisms between GEP-NET and control group (p=0.0006) as well as in the frequency of G-allele (p=0.010). G-allele correlated with higher IL-2 serum levels (p=0.028), elevated in all patients, being highest in patients with functional tumors (p=0.039). Compared to CgA and 5-HIAA, IL-2 was more specific in detecting GEP-NET patients (p<0.0001 and p<0.0001, respectively). Our results indicate importance of IL-2 in GEP-NET development and biochemical diagnosis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
098-0982464-2508 - Molekularna genetika i farmakogenetika gastrointestinalnih tumora (Kapitanović, Sanja, MZOS ) ( POIROT)
134-1342428-0491 - Neuroendokrini tumori probavnog sustava i gušterače (Cigrovski Berković, Maja, MZOS ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
KBC "Sestre Milosrdnice",
PLIVA HRVATSKA d.o.o.

Citiraj ovu publikaciju

Cigrovski Berković, Maja; Jokić, Mladen; Marout, Jasminka; Radošević, Senka; Zjačić-Rotkvić, Vanja; Kapitanović, Sanja
IL-2 -330 T/G SNP and serum values - potential new tumor markers in neuroendocrine tumors of the gastrointestinal tract and pancreas (GEP-NETs) // Journal of molecular medicine, 88 (2010), 4; 423-429 doi:10.1007/s00109-009-0581-x (međunarodna recenzija, članak, znanstveni)
Cigrovski Berković, M., Jokić, M., Marout, J., Radošević, S., Zjačić-Rotkvić, V. & Kapitanović, S. (2010) IL-2 -330 T/G SNP and serum values - potential new tumor markers in neuroendocrine tumors of the gastrointestinal tract and pancreas (GEP-NETs). Journal of molecular medicine, 88 (4), 423-429 doi:10.1007/s00109-009-0581-x.
@article{article, year = {2010}, pages = {423-429}, DOI = {10.1007/s00109-009-0581-x}, keywords = {IL2, regulatory polymorphism, GEP-NET, susceptibility, tumor marker}, journal = {Journal of molecular medicine}, doi = {10.1007/s00109-009-0581-x}, volume = {88}, number = {4}, issn = {0946-2716}, title = {IL-2 -330 T/G SNP and serum values - potential new tumor markers in neuroendocrine tumors of the gastrointestinal tract and pancreas (GEP-NETs)}, keyword = {IL2, regulatory polymorphism, GEP-NET, susceptibility, tumor marker} }
@article{article, year = {2010}, pages = {423-429}, DOI = {10.1007/s00109-009-0581-x}, keywords = {IL2, regulatory polymorphism, GEP-NET, susceptibility, tumor marker}, journal = {Journal of molecular medicine}, doi = {10.1007/s00109-009-0581-x}, volume = {88}, number = {4}, issn = {0946-2716}, title = {IL-2 -330 T/G SNP and serum values - potential new tumor markers in neuroendocrine tumors of the gastrointestinal tract and pancreas (GEP-NETs)}, keyword = {IL2, regulatory polymorphism, GEP-NET, susceptibility, tumor marker} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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