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Pregled bibliografske jedinice broj: 437066

Heritabilities of ocular biometrical traits in 2 Croatian isolates with extended pedigrees


Vitart, Veronique; Benčić, Goran; Hayward, Caroline; Herman Skunca, Jelena; Huffman , Jennifer; Campbell, Susan; Bućan, Kajo; Zgaga, Lina; Kolčić, Ivana; Polašek, Ozren et al.
Heritabilities of ocular biometrical traits in 2 Croatian isolates with extended pedigrees // Investigative ophthalmology & visual science, 51 (2010), 2; 737-747 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 437066 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Heritabilities of ocular biometrical traits in 2 Croatian isolates with extended pedigrees

Autori
Vitart, Veronique ; Benčić, Goran ; Hayward, Caroline ; Herman Skunca, Jelena ; Huffman , Jennifer ; Campbell, Susan ; Bućan, Kajo ; Zgaga, Lina ; Kolčić, Ivana ; Polašek, Ozren ; Campbell, Harry ; Wright, Alan ; Vatavuk, Zoran ; Rudan, Igor

Izvornik
Investigative ophthalmology & visual science (0146-0404) 51 (2010), 2; 737-747

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
oculometric traits; heritability; isolate population; stature

Sažetak
To assess the effects of body stature and years of education, in addition to age and sex, on 6 oculometric traits and to estimate the heritabilities of these quantitative traits in 2 Croatian cross-population studies. Adult subjects living on the 2 Croatian islands of Vis and Korcula were recruited for a large epidemiological and genetic study, which included eye biometry, keratometry and autorefraction. Effects and heritabilities were estimated using general linear mixed models for: axial length (AL), anterior chamber depth (ACD), corneal curvature (CC), corneal thickness (CT), lens thickness (LT), and spherical equivalent refraction (SER). Both cohorts have been genotyped using dense SNP arrays allowing to use kinship coefficients derived from genotypic data (realised kinship) rather than from pedigree information (expected kinship). Across cohorts, body mass index (BMI) did not consistently influence any of the ocular traits adjusted for age and/or sex, while height and years in education (YrEd) did, explaining up to an additional 5% of the variance (for CC). CT was the trait the least influenced by covariates. Estimated heritabilities, in respectively Vis and Korcula, were 84% and 52% for CC, 75% and 71% for CT, 37% and 32% for LT, 59% and 45% for ACD, 37% and 74% for AL, and 0% and 17% for SER. While heritabilities for CT and CC seem uniformly high across studies of Caucasian datasets, estimates for SER vary widely and were at the lower end of the spectrum of published observations in our study.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekti:
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Polašek, Ozren, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Medicinski fakultet, Split

Profili:

Avatar Url Zoran Vatavuk (autor)

Avatar Url Ozren Polašek (autor)

Avatar Url Lina Zgaga (autor)

Avatar Url Goran Benčić (autor)

Avatar Url Igor Rudan (autor)

Avatar Url Kajo Bućan (autor)

Avatar Url Ivana Kolčić (autor)


Citiraj ovu publikaciju:

Vitart, Veronique; Benčić, Goran; Hayward, Caroline; Herman Skunca, Jelena; Huffman , Jennifer; Campbell, Susan; Bućan, Kajo; Zgaga, Lina; Kolčić, Ivana; Polašek, Ozren et al.
Heritabilities of ocular biometrical traits in 2 Croatian isolates with extended pedigrees // Investigative ophthalmology & visual science, 51 (2010), 2; 737-747 (međunarodna recenzija, članak, znanstveni)
Vitart, V., Benčić, G., Hayward, C., Herman Skunca, J., Huffman , J., Campbell, S., Bućan, K., Zgaga, L., Kolčić, I. & Polašek, O. (2010) Heritabilities of ocular biometrical traits in 2 Croatian isolates with extended pedigrees. Investigative ophthalmology & visual science, 51 (2), 737-747.
@article{article, author = {Vitart, Veronique and Ben\v{c}i\'{c}, Goran and Hayward, Caroline and Herman Skunca, Jelena and Huffman, Jennifer and Campbell, Susan and Bu\'{c}an, Kajo and Zgaga, Lina and Kol\v{c}i\'{c}, Ivana and Pola\v{s}ek, Ozren and Campbell, Harry and Wright, Alan and Vatavuk, Zoran and Rudan, Igor}, year = {2010}, pages = {737-747}, keywords = {oculometric traits, heritability, isolate population, stature}, journal = {Investigative ophthalmology and visual science}, volume = {51}, number = {2}, issn = {0146-0404}, title = {Heritabilities of ocular biometrical traits in 2 Croatian isolates with extended pedigrees}, keyword = {oculometric traits, heritability, isolate population, stature} }
@article{article, author = {Vitart, Veronique and Ben\v{c}i\'{c}, Goran and Hayward, Caroline and Herman Skunca, Jelena and Huffman, Jennifer and Campbell, Susan and Bu\'{c}an, Kajo and Zgaga, Lina and Kol\v{c}i\'{c}, Ivana and Pola\v{s}ek, Ozren and Campbell, Harry and Wright, Alan and Vatavuk, Zoran and Rudan, Igor}, year = {2010}, pages = {737-747}, keywords = {oculometric traits, heritability, isolate population, stature}, journal = {Investigative ophthalmology and visual science}, volume = {51}, number = {2}, issn = {0146-0404}, title = {Heritabilities of ocular biometrical traits in 2 Croatian isolates with extended pedigrees}, keyword = {oculometric traits, heritability, isolate population, stature} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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