engleski

Chloroperoxidase-catalyzed Chlorination of Didechloroaglucovancomycin and Vancomycin

The chloroperoxidase (CPO) from Caldariomyces fumago catalyzed the chlorination of didechloroaglucovancomycin and vancomycin in the presence of hydrogen peroxide and chloride ion. Chlorination of didechloroaglucovancomycin has afforded new derivatives, with one and two chlorine atoms attached onto the aromatic ring of the residue 7 of didechloroaglucovancomycin. Vancomycin was similarly chlorinated under the same conditions to furnish a new dichloro derivative.

chloroperoxidase; vancomycin; enzymatic chlorination; antibiotics; biotransformation

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