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The variability and specificity of PAPP-A and free β-hCG in the first trimester Down syndrome screening (CROSBI ID 556758)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Sabolović-Rudman, Senka ; Kulaš, Ivana ; Košec, Vesna ; Herman, Radoslav ; Tišlarić-Medenjak, Dubravka The variability and specificity of PAPP-A and free β-hCG in the first trimester Down syndrome screening // Journal of Perinatal Medicine - Abstracts 9th World Congress of Perinatal Medicine. Berlin: Walter de Gruyter, 2009. str. 311-311

Podaci o odgovornosti

Sabolović-Rudman, Senka ; Kulaš, Ivana ; Košec, Vesna ; Herman, Radoslav ; Tišlarić-Medenjak, Dubravka

engleski

The variability and specificity of PAPP-A and free β-hCG in the first trimester Down syndrome screening

Aim: To assess the specificity of biochemical markers: free β-hCG and PAPP-A during the first trimester of pregnancy and to determine the variability of maternal serum concentrations of studied markers between 10+3 and 13+6 weeks of gestation. Subjects: The study population comprised 2883 unaffected, singleton, non-diabetic and spontaneously conceived pregnancies. Pregnant women were separated in 4 groups, depending on the weeks of gestation when biochemical analyzes were performed. Methods: The concentrations of free β-hCG and PAPP-A in maternal serum were determined by solid-phase, enzyme-labeled chemiluminiscent immunometric assay (DPC-Immulite). Concentrations were converted to MoMs. according to centre-specific weighted regression median curves for free β-hCG and PAPP-A, obtained on daily median values for unaffected pregnancies. Results: There were no significant differences between sub-groups, according to the maternal age, maternal weight and the proportion of smokers. significant difference in log10 MoM values of free β-hCG (p<0, 05) was found between 11. and 12. weeks of gestation. Significant differences were ascertained for log10 MoM PAPP-A values between 11. and 12., as well as between 12. and 13. weeks of gestation (p<0, 05). False-positive rates of biochemical risk for trisomy 21 were 16, 1% before the 11th week, 12, 8% between weeks 11 and 11+6, 11, 9% between weeks 12 and 12+6, and 9, 9% after week 13. The differences in proportions were not statistically significant (χ2=0, 813, p=0, 37). Conclusion: Although MoM values of maternal serum free β-hCG and PAPP-A showed certain variations between 10th and 14th week of gestation, the impact on specificity of biochemical markers in study population was not satistically significant.

first-trimester screening; Down syndrome; specificity of biochemical markers

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Podaci o prilogu

311-311.

2009.

objavljeno

Podaci o matičnoj publikaciji

Journal of Perinatal Medicine - Abstracts 9th World Congress of Perinatal Medicine

Berlin: Walter de Gruyter

Podaci o skupu

9th World Congress of Perinatal medicine

poster

24.09.2009-28.09.2009

Berlin, Njemačka

Povezanost rada

Kliničke medicinske znanosti