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Pregled bibliografske jedinice broj: 434993

Single intracerebroventricular injection of botulinum toxin type A produces slow onset and long-term memory impairment in rats


Lacković, Zdravko; Rebić, Veseljka; Riederer, Peter
Single intracerebroventricular injection of botulinum toxin type A produces slow onset and long-term memory impairment in rats // Journal of Neural Transmission, 116 (2009), 10; 1273-1280 (međunarodna recenzija, članak, znanstveni)


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Naslov
Single intracerebroventricular injection of botulinum toxin type A produces slow onset and long-term memory impairment in rats

Autori
Lacković, Zdravko ; Rebić, Veseljka ; Riederer, Peter

Izvornik
Journal of Neural Transmission (0300-9564) 116 (2009), 10; 1273-1280

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Botulinum toxin; Botulinum toxin type A; Cognitive impairment; Intracerebroventricular application; Morris water maze; Rat; Dementia

Sažetak
It is generally believed that the cholinergic system plays an important role in normal cognitive functioning. Botulinum toxin is the most potent toxin of the peripheral cholinergic system and today it is used in the treatment of a variety of neurological disorders. However, it is surprising that its effect on cognitive processes has been investigated in only two publications. Short-term effects of the central application of botulinum toxin (BTX) type B have been associated with cognitive impairment in animals, while results with type A are ambiguous. In the present study, we have investigated the duration of memory impairment after an intracerebroventricular administration of BTX-A in rats. Two experiments were performed, lasting 12 and 5 months, respectively. In both experiments, the same dose of BTX-A was applied (2 U/kg) and the Morris water maze test was used in the assessment of memory performance. Results show that a single icv injection of a small dose of BTX-A significantly impairs the water maze performance. In both experiments, impairment was apparently of a slow onset and long lasting (up to 12 months). The length and pattern of attenuation suggest development of dementia-like deficits. In addition to providing a potentially new experimental model of memory impairment, these results question the idea of an intracranial application of BTX in the treatment of CNS disorders.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekt / tema
108-1080003-0001 - NEUROTRANSMITORI I NOVI MEHANIZMI DJELOVANJA LIJEKOVA I OTROVA (Lackovic, Zdravko, MZOS - )

Ustanove
Medicinski fakultet, Zagreb

Profili:

Avatar Url Zdravko Lacković (autor)

Avatar Url Veseljka Rebić (autor)

Citiraj ovu publikaciju

Lacković, Zdravko; Rebić, Veseljka; Riederer, Peter
Single intracerebroventricular injection of botulinum toxin type A produces slow onset and long-term memory impairment in rats // Journal of Neural Transmission, 116 (2009), 10; 1273-1280 (međunarodna recenzija, članak, znanstveni)
Lacković, Z., Rebić, V. & Riederer, P. (2009) Single intracerebroventricular injection of botulinum toxin type A produces slow onset and long-term memory impairment in rats. Journal of Neural Transmission, 116 (10), 1273-1280.
@article{article, year = {2009}, pages = {1273-1280}, keywords = {Botulinum toxin, Botulinum toxin type A, Cognitive impairment, Intracerebroventricular application, Morris water maze, Rat, Dementia}, journal = {Journal of Neural Transmission}, volume = {116}, number = {10}, issn = {0300-9564}, title = {Single intracerebroventricular injection of botulinum toxin type A produces slow onset and long-term memory impairment in rats}, keyword = {Botulinum toxin, Botulinum toxin type A, Cognitive impairment, Intracerebroventricular application, Morris water maze, Rat, Dementia} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • MEDLINE





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