engleski

Cationic side-chains control DNA/RNA binding properties and antiproliferative activity of dicationic dibenzotetraaza[14]annulene derivatives

Studied dicationic dibenzotetraaza[14]annulene derivatives intercalate into synthetic double stranded DNA and RNA, while their positively charged side-chains additionally interact within the minor groove of polynucleotides, contributing to the overall affinity of compounds and controlling pronounced A-T(U) over G-C sequence preference as well as stronger thermal stabilization of ds-DNA than ds-RNA. Furthermore, all compounds showed moderate to high antiproliferative activity against five human tumour cell lines, whereby clear correlation between structure of the side-chain and cytotoxic activity was observed.

dibenzotetraaza[14]annulene ; DNA and RNA polynucleotides ; spectrophotometric titrations ; antiproliferative activity ; tumour cell lines

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