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Pregled bibliografske jedinice broj: 434423

Surveillance of Croatian pregnant women with epilepsy and effects of antiepileptic drugs exposure in their offspring


Miškov, Snježana; Gjergja Juraški, R; Fučić, A; Ivičević Bakulić, T; Mikula, Ivan; Cvitanović Šojat, Lj.; Bošnjak, Jelena; Demarin, Vida
Surveillance of Croatian pregnant women with epilepsy and effects of antiepileptic drugs exposure in their offspring // Journal of the Neurological Sciences, Vol.285, Suppl.1 / Lisak, R.P. (ur.).
Bangkok, Tajland: Elsevier, 2009. (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 434423 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Surveillance of Croatian pregnant women with epilepsy and effects of antiepileptic drugs exposure in their offspring

Autori
Miškov, Snježana ; Gjergja Juraški, R ; Fučić, A ; Ivičević Bakulić, T ; Mikula, Ivan ; Cvitanović Šojat, Lj. ; Bošnjak, Jelena ; Demarin, Vida

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of the Neurological Sciences, Vol.285, Suppl.1 / Lisak, R.P. - : Elsevier, 2009

Skup
19th World Congress of Neurology

Mjesto i datum
Bangkok, Tajland, 24-30.10.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
pregnant; epilepsy; antiepileptic drugs

Sažetak
Purpose: The aim was to follow up pregnancies exposed to AED and their offspring in order to assess teratogenic and neurodevelopmental effect of particular AED of newer generation. Methods: The study is prospective surveillance of pregnancies in Croatian women with epilepsy from May 2003 to May 2009. The data about pregnancy planning, folate supplementation, seizure frequency and AED therapy were obtained. The results were compared with healthy controls (mother/newborn pairs). Results: We have surveyed 68 pregnancies from 52 women: 91% (62/68) were exposed to monotherapy: 33 to lamotrigine (LTG): 19 live-births (LB), 2 premature deliveries (one with motor delay), 3 spontaneous abortions (SA), 1 artificial abortion, 1 intrauterine death and 7 ongoing pregnancies (OP). Eleven LB and 2 SA were exposed to carbamazepine (CBZ), 1 LB was under phenitoine (PHT) and 1 under phenobarbiton (PB) with EPH gestosis/peripartal asphyxia. One LB and 1 preterm LB with ASD, severe psychomotor delay and epilepsy was exposed to gabapentine (GBP), 5 LB and 1 OP were under valproic acid (VP). Two pregnancies were under meprobamate (MPB): 1 LB and 1 SA. Six pregnancies were exposed to polytherapy: 1 LB, 1 SA and 1 OP to topiramate (TPM) and VP, 1 still-birth to CBZ and PB, 1 LB with intrauterine growth retardation and dysmorphism to TPM, CBZ, PHT, and 1 OP to VP and clonazepam (CZP). Four pregnancies without AED resulted in healthy LB. About 35% of women have planned their pregnancy, but only 20% took folic acid periconceptionaly. Conclusion: We have surveyed pregnancies exposed to LTG, VP, PHT, PB, GBP, TMP, CBZ, MPB and CZP. AED polytherapy resulted in larger proportion of complications. Adequate preconceptional counseling in women with epilepsy resulted in higher proportion of pregnancy planning and folic acid intake. Further

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
134-1340036-0035 - Uloga vaskularnih čimbenika rizika u patogenezi Alzheimerove bolesti (Zlatko Trkanjec, )
134-1340036-0034 - Funkcijska dijagnostika moždane cirkulacije (Arijana Lovrenčić-Huzjan, )
134-1340036-0033 - Uloga genetskih markera u razvoju cerebralne aterosklerotske bolesti (Vida Demarin, )

Ustanove
KBC "Sestre Milosrdnice"

Citiraj ovu publikaciju

Miškov, Snježana; Gjergja Juraški, R; Fučić, A; Ivičević Bakulić, T; Mikula, Ivan; Cvitanović Šojat, Lj.; Bošnjak, Jelena; Demarin, Vida
Surveillance of Croatian pregnant women with epilepsy and effects of antiepileptic drugs exposure in their offspring // Journal of the Neurological Sciences, Vol.285, Suppl.1 / Lisak, R.P. (ur.).
Bangkok, Tajland: Elsevier, 2009. (poster, međunarodna recenzija, sažetak, znanstveni)
Miškov, S., Gjergja Juraški, R., Fučić, A., Ivičević Bakulić, T., Mikula, I., Cvitanović Šojat, L., Bošnjak, J. & Demarin, V. (2009) Surveillance of Croatian pregnant women with epilepsy and effects of antiepileptic drugs exposure in their offspring. U: Lisak, R. (ur.)Journal of the Neurological Sciences, Vol.285, Suppl.1.
@article{article, editor = {Lisak, R.}, year = {2009}, pages = {S256}, keywords = {pregnant, epilepsy, antiepileptic drugs}, title = {Surveillance of Croatian pregnant women with epilepsy and effects of antiepileptic drugs exposure in their offspring}, keyword = {pregnant, epilepsy, antiepileptic drugs}, publisher = {Elsevier}, publisherplace = {Bangkok, Tajland} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE