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4-Hydroxynonenal-protein adducts as biomarkers of oxidative stress, lipid peroxidation and oxidative homeostasis


Žarković, Neven; Čipak Gasparović, Ana; Cindrić, Marina; Waeg, Georg; Borović Šunjić, Suzana; Mrakovčić, Lidija; Jaganjac, Morana; Kolenc, Danijela; Andrišić, Luka; Gverić Ahmetašević, Snježana et al.
4-Hydroxynonenal-protein adducts as biomarkers of oxidative stress, lipid peroxidation and oxidative homeostasis // Free Radicals Health and Lifestyle : contributions from the Europe Meeting of the Society for Free Radical Research / Caporossi, Daniela ; Pigozzi, Fabio ; Sabatini Stefania (ur.).
Rim: Medimond International Proceedings, 2009. str. 37-44 (predavanje, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)


Naslov
4-Hydroxynonenal-protein adducts as biomarkers of oxidative stress, lipid peroxidation and oxidative homeostasis

Autori
Žarković, Neven ; Čipak Gasparović, Ana ; Cindrić, Marina ; Waeg, Georg ; Borović Šunjić, Suzana ; Mrakovčić, Lidija ; Jaganjac, Morana ; Kolenc, Danijela ; Andrišić, Luka ; Gverić Ahmetašević, Snježana ; Katušić, Ana ; Cherkas, Andriy ; Jurić Sekhar, Gordana ; Wildburger, Renate ; Žarković, Kamelija

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Free Radicals Health and Lifestyle : contributions from the Europe Meeting of the Society for Free Radical Research / Caporossi, Daniela ; Pigozzi, Fabio ; Sabatini Stefania - Rim : Medimond International Proceedings, 2009, 37-44

ISBN
978-88-7587-515-2

Skup
Free Radicals Health and Lifestyle

Mjesto i datum
Rim, Italija, 26.-29.08.2009.

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
4-hydroxynonenal; lipid peroxidation; oxidative stress; oxidative homeostasis

Sažetak
Lipid peroxidation and its end products reactive aldehydes are implicated in pathogenesis of various diseases such as cardiovascular diseases, neurodegenerative diseases, diabetes mellitus and cancer. 4-hydroxy-2-nonenal (HNE) is the most intriguing one due to its involvement in various (patho)physiological processes. The concept of HNE as toxic messenger of free radicals evolved further into the concept of HNE as biomarker, growth regulating factor and signalling molecule. That allowed consideration of oxidative stress also as physiological process introducing new term ”oxidative homeostasis”, which implies involvements of reactive oxygen species (ROS) and lipid peroxidation in various physiological processes. According to such concept of oxidative homeostasis, the HNE-protein adducts should be present not only under pathological but also under physiological circumstances in various human and animal tissues, as revealed in this article showing briefly results of several genuine immunohistochemical studies.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2519 - Lipidi, slobodni radikali i njihovi glasnici u integrativnoj onkologiji (Neven Žarković, )
108-0000000-0028 - Oksidacijski stres i tumori središnjeg živčanog sustava (Kamelija Žarković, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb