engleski

Ferrocene Compounds. XXI. Synthesis of Some beta-Aryl-beta-ferrocenylpropionic Acids and beta, beta-(1, 1'-Ferrocenylene)bis(beta-arylpropionic Acids)

Reaction of several alpha-substituted ferrocenylmethanols (1) with diethyl malonate gave condensation products (3), which were hydrolized and decarboxylated to beta-ferrocenylbutyric acid (6a) and beta-aryl-beta-ferrocenylpropionic acids (6b-6e). Similarly, starting from alpha, alpha'-disubstituted 1, 1'-ferrocenylene-bismethanols (2) beta, beta-(1, 1'-ferrocenylene)bis(butyric acid) (11a) and beta, beta-(1, 1'-ferrocenylene)bis(beta-arylpropionic acids) (11b-11e) have been obtained via (8) and (9). The mechanism of these condensation reactions which includes transesterification of diethylmalonate with carbinols (1) and (2) has been proposed.

Ferrocenylpropionic acid; condensation; transesterification

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