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Pregled bibliografske jedinice broj: 431469

Genetic markers in suicidal and non-suicidal veterans with combat-related posttraumatic stress disorder


Pivac, Nela; Kozarić-Kovačić, Dragica; Nedić, Gordana; Nikolac, Matea; Mustapić, Maja; Babić, Ana; Grubišić-Ilić, Mirjana; Kovačić, Zrnka; Muck-Šeler, Dorotea
Genetic markers in suicidal and non-suicidal veterans with combat-related posttraumatic stress disorder // Wounds of War II: Addressing Posttraumatic Stress Disorder in Peacekeeping and Combat Troops : Program guide / Wiederhold, Brenda K. (ur.).
San Diego: NATO, 2009. str. 19-19 (plenarno, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 431469 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Genetic markers in suicidal and non-suicidal veterans with combat-related posttraumatic stress disorder

Autori
Pivac, Nela ; Kozarić-Kovačić, Dragica ; Nedić, Gordana ; Nikolac, Matea ; Mustapić, Maja ; Babić, Ana ; Grubišić-Ilić, Mirjana ; Kovačić, Zrnka ; Muck-Šeler, Dorotea

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Wounds of War II: Addressing Posttraumatic Stress Disorder in Peacekeeping and Combat Troops : Program guide / Wiederhold, Brenda K. - San Diego : NATO, 2009, 19-19

Skup
Wounds of War II: Addressing Posttraumatic Stress Disorder in Peacekeeping and Combat Troops

Mjesto i datum
St. Kanzian, Klopeiner See, Austrija, 18.-22.10.2009

Vrsta sudjelovanja
Plenarno

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
the genes for monoamine oxidase (MAO-B); dopamine-beta-hydroxylase (DBH); COMT; BDNF; serotonin transporter (5-HTT) and serotonin 5HT2A receptor; male Croatian war veterans; combat related PTSD; suicidal behavior

Sažetak
Posttraumatic stress disorder (PTSD) is a complex polygenic psychiatric disorder, precipitated by an exposure to a traumatic event. The risk factors for PTSD include, besides traumatic experience, other biological, genetic, environmental factors, and adversity in early life. Genetic studies in PTSD are still scarce. Combat-related PTSD is especially pervasive form of PTSD, frequently associated with suicidal behavior. Various markers of serotonin (5-HT), dopamine, noradrenalin, hypothalamic-pituitary-adrenal axis function, brain derived neurotrophic factor (BDNF), and catechol-o-methyltransferase (COMT) have been proposed as the possible markers of PTSD and/or suicidal behavior. Our study determined polymorphisms of the genes for monoamine oxidase (MAO-B), dopamine-beta-hydroxylase (DBH), COMT, BDNF, serotonin transporter (5-HTT) and serotonin 5HT2A receptor in male Croatian war veterans with combat related PTSD, subdivided into non-suicidal and suicidal subjects. There were no significant differences in the frequencies of the genotypes or alleles for MAO-B, -1021C/T DBH, Val158/108Met COMT, Val66Met BDNF, 5-HTTLPR and 102T/C 5HT2A between suicidal and non-suicidal veterans with PTSD. Our results did not support the hypothesis that these genetic variants contributed to the risk of suicidal behavior in combat- related PTSD. Since both suicidal behavior and clinical features of PTSD are heterogeneous and complex, the research of the risk genes is associated with numerous methodological difficulties, especially with the problem of detecting a significant effect. The identification of subjects prone to suicidal behavior is important for the prevention of suicidal attempts and proper treatment interventions, and therefore future studies should elucidate the relationship between candidate genetic risk factors and suicidal behavior in the large homogenous sample of veterans with PTSD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
098-0982522-2455 - Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja (Pivac, Nela, MZOS ) ( POIROT)
098-0982522-2457 - Farmakogenomika i proteomika serotoninskog i kateholaminskog sustava (Muck-Šeler, Dorotea, MZOS ) ( POIROT)
198-0982522-0075 - Psihofiziološka dijagnostika poremećaja uzrokovanih stresom (Kozarić-Kovačić, Dragica, MZOS ) ( POIROT)
198-1081870-0074 - Utjecaj lipidnog statusa, homocisteina i oLAB-a na kognitivne funkcije u PTSP-u (Rak, Davor, MZOS ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Klinička bolnica "Dubrava"


Citiraj ovu publikaciju

Pivac, Nela; Kozarić-Kovačić, Dragica; Nedić, Gordana; Nikolac, Matea; Mustapić, Maja; Babić, Ana; Grubišić-Ilić, Mirjana; Kovačić, Zrnka; Muck-Šeler, Dorotea
Genetic markers in suicidal and non-suicidal veterans with combat-related posttraumatic stress disorder // Wounds of War II: Addressing Posttraumatic Stress Disorder in Peacekeeping and Combat Troops : Program guide / Wiederhold, Brenda K. (ur.).
San Diego: NATO, 2009. str. 19-19 (plenarno, međunarodna recenzija, sažetak, znanstveni)
Pivac, N., Kozarić-Kovačić, D., Nedić, G., Nikolac, M., Mustapić, M., Babić, A., Grubišić-Ilić, M., Kovačić, Z. & Muck-Šeler, D. (2009) Genetic markers in suicidal and non-suicidal veterans with combat-related posttraumatic stress disorder. U: Wiederhold, B. (ur.)Wounds of War II: Addressing Posttraumatic Stress Disorder in Peacekeeping and Combat Troops : Program guide.
@article{article, editor = {Wiederhold, B.}, year = {2009}, pages = {19-19}, keywords = {the genes for monoamine oxidase (MAO-B), dopamine-beta-hydroxylase (DBH), COMT, BDNF, serotonin transporter (5-HTT) and serotonin 5HT2A receptor, male Croatian war veterans, combat related PTSD, suicidal behavior}, title = {Genetic markers in suicidal and non-suicidal veterans with combat-related posttraumatic stress disorder}, keyword = {the genes for monoamine oxidase (MAO-B), dopamine-beta-hydroxylase (DBH), COMT, BDNF, serotonin transporter (5-HTT) and serotonin 5HT2A receptor, male Croatian war veterans, combat related PTSD, suicidal behavior}, publisher = {NATO}, publisherplace = {St. Kanzian, Klopeiner See, Austrija} }
@article{article, editor = {Wiederhold, B.}, year = {2009}, pages = {19-19}, keywords = {the genes for monoamine oxidase (MAO-B), dopamine-beta-hydroxylase (DBH), COMT, BDNF, serotonin transporter (5-HTT) and serotonin 5HT2A receptor, male Croatian war veterans, combat related PTSD, suicidal behavior}, title = {Genetic markers in suicidal and non-suicidal veterans with combat-related posttraumatic stress disorder}, keyword = {the genes for monoamine oxidase (MAO-B), dopamine-beta-hydroxylase (DBH), COMT, BDNF, serotonin transporter (5-HTT) and serotonin 5HT2A receptor, male Croatian war veterans, combat related PTSD, suicidal behavior}, publisher = {NATO}, publisherplace = {St. Kanzian, Klopeiner See, Austrija} }




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