engleski

Cognitive changes and genetic markers in amyotrohic lateral sclerosis

Amyotrophic lateral sclerosis is increasingly recognized as a multisystem disorder which includes motor system deficit and non-motor impairments in a spectrum of clinical features of frontotemporal dementia (FTD). The overlap between cognitive impairment and behavioral features is demonstrated in up to 50% of ALS patients. Behavioral features are mostly due to changes in serotonergic and catecholaminergic system. Therefore, we aimed to identify gene polymorphisms for proteins involved in serotonin and catecholamine metabolism and function with the emphasis on executive function in ALS patients. In a prospective study, 18 ALS patients (10 male, 60.5+/-5.8 yrs) defined by El Escorial Criteria were investigated. ... We did not find correlations between gene polymorphisms and variables of executive functional test. A sizeble proportion of ALS patients' showed behavioural and cognitive changes within a spectrum of FTD.

cognitive impairment ; genetic markers ; ALS ; FTD

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