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Pregled bibliografske jedinice broj: 43106

Chelation of aluminium by combining DFO and L1 in rats

Blanuša, Maja; Prester, Ljerka; Varnai, Veda Marija; Pavlović, Draško; Kostial, Krista; Jones, Mark M.; Singh, Pramod K.
Chelation of aluminium by combining DFO and L1 in rats // Toxicology, 147 (2000), 3; 151-156 (međunarodna recenzija, članak, znanstveni)

Chelation of aluminium by combining DFO and L1 in rats

Blanuša, Maja ; Prester, Ljerka ; Varnai, Veda Marija ; Pavlović, Draško ; Kostial, Krista ; Jones, Mark M. ; Singh, Pramod K.

Toxicology (0300-483X) 147 (2000), 3; 151-156

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Chelation ; 1 ; 2 dimethyl-3-hydroxypyrid-4-one ; desferrioxamine ; aluminium ; iron ; urine ; serum

The hypothesis that two known chelators 1, 2-dimethyl-3-hydroxypyrid-4-one (L1) and desferrioxamine (DFO) might be more efficient as combined treatment than as monotherapies in removing aluminium from the body was tested in a new acute rat model. Five-week old female rats received chelators: L1 (p.o.), DFO (i.p.) or L1 + DFO as 100 or 200 mg/kg dose half an hour after a single i.p. administration of 6 mg Al/kg body weight in the form of chloride. Serum aluminium concentration and urinary aluminium and iron excretions were determined by electrothermal or flame atomic absorption spectrometry. Both chelators were effective only at the higher dose level. While DFO was more effective than L1 in enhancing urinary aluminium excretion, L1 was more effective than DFO in enhancing urinary iron excretion. In the combined treatment group L1 did not increase the DFO effect on aluminium and DFO did not increase the effect of L1 on iron elimination. However, in this group a simultaneous increase in both aluminium and iron elimination was observed. Our results support the usefulness of this animal model for preliminary in vivo testing of aluminium chelators. Urinary values were more useful because of the high variability of serum results. Result of combined chelators treatment should be confirmed in a different experimental model before extrapolation to other systems. This testing procedure of course does not provide all the relevant answers for evaluating the efficiency of chelating agents in aluminium toxicity.

Izvorni jezik

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita


Projekt / tema

Institut za medicinska istraživanja i medicinu rada, Zagreb

Časopis indeksira:

  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus

Uključenost u ostale bibliografske baze podataka:

  • Biological Abstracts
  • Chemical Abstracts
  • Excerpta Medica
  • Index Medicus
  • Biological Abstracts
  • Excerpta Medica
  • Index Medicus
  • Elsevier BIOBASE/Current Awareness in Biological Sciences
  • Cambridge Scientific Abstracts
  • Environmental Mutagene Information Center
  • Environmental Periodicals Bibliography