Applicability of RP-TLC method for the assessment of lipophilicity of beta-lactams used in treatment of CNS infections (CROSBI ID 555866)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Bojić, Mirza ; Mirat, Alemka ; Medić-Šarić, Marica ; Rajić, Zrinka
engleski
Applicability of RP-TLC method for the assessment of lipophilicity of beta-lactams used in treatment of CNS infections
80 years have passed since Fleming published discovery of penicillin. Beta-lactams have been for years the safest and most efficient antibiotics owing it to the specific action on bacterial cell wall. Nowadays, beta-lactams are in their renaissance as multipotent agents against neurological diseases (e.g. amylotrophic lateral sclerosis, Alzheimer, Parkinson and prion diseases). Thus their lipophilicity, as major characteristic determining passage through blood-brain barrier, is of grate importance for their targeted delivery. As TLC is relatively inexpensive and time saving method we decided to characterise each beta-lactam with chromatographic parameters RM0 and φ 0 using linear solvent strength model. Although LSS models for other beta- lactams were suitable, RP-TLC should be used as indicative rather than quantitative measurement for characterisation of lipophilicity of beta-lactams in methanol-water systems.
RP-TLC; lipophilicity; beta-lactams
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Podaci o prilogu
196-197.
2009.
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objavljeno
Podaci o matičnoj publikaciji
European journal of pharmaceutical sciences
Hincal, Atilla ; Celebi, Nevin ; Yuksel, Nilufer
Elsevier
0928-0987
Podaci o skupu
3rd BBBB-Bosporus International Conference on Pharmaceutical Sciences
poster
26.10.2009-28.10.2009
Antalya, Turska