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Applicability of RP-TLC method for the assessment of lipophilicity of beta-lactams used in treatment of CNS infections (CROSBI ID 555866)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Bojić, Mirza ; Mirat, Alemka ; Medić-Šarić, Marica ; Rajić, Zrinka Applicability of RP-TLC method for the assessment of lipophilicity of beta-lactams used in treatment of CNS infections // European journal of pharmaceutical sciences / Hincal, Atilla ; Celebi, Nevin ; Yuksel, Nilufer (ur.). 2009. str. 196-197

Podaci o odgovornosti

Bojić, Mirza ; Mirat, Alemka ; Medić-Šarić, Marica ; Rajić, Zrinka

engleski

Applicability of RP-TLC method for the assessment of lipophilicity of beta-lactams used in treatment of CNS infections

80 years have passed since Fleming published discovery of penicillin. Beta-lactams have been for years the safest and most efficient antibiotics owing it to the specific action on bacterial cell wall. Nowadays, beta-lactams are in their renaissance as multipotent agents against neurological diseases (e.g. amylotrophic lateral sclerosis, Alzheimer, Parkinson and prion diseases). Thus their lipophilicity, as major characteristic determining passage through blood-brain barrier, is of grate importance for their targeted delivery. As TLC is relatively inexpensive and time saving method we decided to characterise each beta-lactam with chromatographic parameters RM0 and φ 0 using linear solvent strength model. Although LSS models for other beta- lactams were suitable, RP-TLC should be used as indicative rather than quantitative measurement for characterisation of lipophilicity of beta-lactams in methanol-water systems.

RP-TLC; lipophilicity; beta-lactams

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Podaci o prilogu

196-197.

2009.

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objavljeno

Podaci o matičnoj publikaciji

European journal of pharmaceutical sciences

Hincal, Atilla ; Celebi, Nevin ; Yuksel, Nilufer

Elsevier

0928-0987

Podaci o skupu

3rd BBBB-Bosporus International Conference on Pharmaceutical Sciences

poster

26.10.2009-28.10.2009

Antalya, Turska

Povezanost rada

Farmacija

Indeksiranost