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Pregled bibliografske jedinice broj: 430923

Applicability of RP-TLC method for the assessment of lipophilicity of beta-lactams used in treatment of CNS infections


Bojić, Mirza; Mirat, Alemka; Medić-Šarić, Marica; Rajić, Zrinka
Applicability of RP-TLC method for the assessment of lipophilicity of beta-lactams used in treatment of CNS infections // European Journal of Pharmaceutical Sciences, Supplement: 3rd BBBB-Bosporus International Conference on Pharmaceutical Sciences / Hincal, Atilla ; Celebi, Nevin ; Yuksel, Nilufer (ur.).
Antalija, Turska: Elsevier, 2009. str. 196-197 (poster, međunarodna recenzija, sažetak, znanstveni)


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Naslov
Applicability of RP-TLC method for the assessment of lipophilicity of beta-lactams used in treatment of CNS infections

Autori
Bojić, Mirza ; Mirat, Alemka ; Medić-Šarić, Marica ; Rajić, Zrinka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of Pharmaceutical Sciences, Supplement: 3rd BBBB-Bosporus International Conference on Pharmaceutical Sciences / Hincal, Atilla ; Celebi, Nevin ; Yuksel, Nilufer - : Elsevier, 2009, 196-197

Skup
3rd BBBB-Bosporus International Conference on Pharmaceutical Sciences

Mjesto i datum
Antalija, Turska, 26-28.10.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
RP-TLC; lipophilicity; beta-lactams

Sažetak
80 years have passed since Fleming published discovery of penicillin. Beta-lactams have been for years the safest and most efficient antibiotics owing it to the specific action on bacterial cell wall. Nowadays, beta-lactams are in their renaissance as multipotent agents against neurological diseases (e.g. amylotrophic lateral sclerosis, Alzheimer, Parkinson and prion diseases). Thus their lipophilicity, as major characteristic determining passage through blood-brain barrier, is of grate importance for their targeted delivery. As TLC is relatively inexpensive and time saving method we decided to characterise each beta-lactam with chromatographic parameters RM0 and φ 0 using linear solvent strength model. Although LSS models for other beta- lactams were suitable, RP-TLC should be used as indicative rather than quantitative measurement for characterisation of lipophilicity of beta-lactams in methanol-water systems.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Projekt / tema
006-0061117-1237 - Biološki aktivni spojevi, metaboliti i QSAR (Marica Medić-Šarić, )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Marica Medić-Šarić (autor)

Avatar Url Zrinka Rajić (autor)

Avatar Url Mirza Bojić (autor)

Citiraj ovu publikaciju

Bojić, Mirza; Mirat, Alemka; Medić-Šarić, Marica; Rajić, Zrinka
Applicability of RP-TLC method for the assessment of lipophilicity of beta-lactams used in treatment of CNS infections // European Journal of Pharmaceutical Sciences, Supplement: 3rd BBBB-Bosporus International Conference on Pharmaceutical Sciences / Hincal, Atilla ; Celebi, Nevin ; Yuksel, Nilufer (ur.).
Antalija, Turska: Elsevier, 2009. str. 196-197 (poster, međunarodna recenzija, sažetak, znanstveni)
Bojić, M., Mirat, A., Medić-Šarić, M. & Rajić, Z. (2009) Applicability of RP-TLC method for the assessment of lipophilicity of beta-lactams used in treatment of CNS infections. U: Hincal, A., Celebi, N. & Yuksel, N. (ur.)European Journal of Pharmaceutical Sciences, Supplement: 3rd BBBB-Bosporus International Conference on Pharmaceutical Sciences.
@article{article, year = {2009}, pages = {196-197}, keywords = {RP-TLC, lipophilicity, beta-lactams}, title = {Applicability of RP-TLC method for the assessment of lipophilicity of beta-lactams used in treatment of CNS infections}, keyword = {RP-TLC, lipophilicity, beta-lactams}, publisher = {Elsevier}, publisherplace = {Antalija, Turska} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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