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Pregled bibliografske jedinice broj: 430863

Intranasal challenge with increasing ovalbumin doses differently affects airway hyperresponsiveness and inflammatory cell accumulation in mouse model of asthma.


Bošnjak, Berislav; Ivetić-Tkalčević, Vanesa; Đurić, Koraljka; Belamarić, Danijela; Čužić, Snježana; Ferenčić, Željko; Brajša, Karmen; Glojnarić, Ines; Antolović, Roberto; Hrvačić, Boška
Intranasal challenge with increasing ovalbumin doses differently affects airway hyperresponsiveness and inflammatory cell accumulation in mouse model of asthma. // Inflammation Research, 58 (2009), 11; 773-781 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 430863 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Intranasal challenge with increasing ovalbumin doses differently affects airway hyperresponsiveness and inflammatory cell accumulation in mouse model of asthma.

Autori
Bošnjak, Berislav ; Ivetić-Tkalčević, Vanesa ; Đurić, Koraljka ; Belamarić, Danijela ; Čužić, Snježana ; Ferenčić, Željko ; Brajša, Karmen ; Glojnarić, Ines ; Antolović, Roberto ; Hrvačić, Boška

Izvornik
Inflammation Research (1023-3830) 58 (2009), 11; 773-781

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
allergen-induced airway hyperresponsiveness (AHR); asthma; BALF

Sažetak
Objective: To investigate whether challenge with increasing allergen doses could differently affect allergen-induced airway hyperresponsiveness (AHR) and inflammatory cell accumulation in mouse model of asthma, providing an experimental model to investigate their relationship. Material and Methods: AHR and accumulation of inflammatory cells in bronchoalveolar lavage fluid (BALF) and into the lungs were compared in ovalbumin-sensitized mice that were challenged intranasally with 2.5, 10, 25 or 100 microg of ovalbumin/mouse. Results: Both AHR and inflammatory cell accumulation were proportional to the ovalbumin dose used for challenge. However, in group challenged with 10 microg of ovalbumin airway inflammation was present, although allergen-induced AHR was not detected. Additional analysis indicated that neither mucous hyperproduction nor eosinophil degranulation could be correlated to presence of AHR in this model, whereas concentration of interleukin (IL)-13 in BALF was increased only in those groups in which AHR was present. Conclusions: Altogether, intranasal challenge of mice with increasing allergen doses could serve as a suitable experimental system for investigation of mechanisms by which airway inflammation leads to allergen-induced AHR. Our initial findings are in line with previous reports that dissociate AHR from amount of eosinophil accumulation and imply the role of IL-13 in this process.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Ustanove:
Fidelta d.o.o.

Citiraj ovu publikaciju

Bošnjak, Berislav; Ivetić-Tkalčević, Vanesa; Đurić, Koraljka; Belamarić, Danijela; Čužić, Snježana; Ferenčić, Željko; Brajša, Karmen; Glojnarić, Ines; Antolović, Roberto; Hrvačić, Boška
Intranasal challenge with increasing ovalbumin doses differently affects airway hyperresponsiveness and inflammatory cell accumulation in mouse model of asthma. // Inflammation Research, 58 (2009), 11; 773-781 (međunarodna recenzija, članak, znanstveni)
Bošnjak, B., Ivetić-Tkalčević, V., Đurić, K., Belamarić, D., Čužić, S., Ferenčić, Ž., Brajša, K., Glojnarić, I., Antolović, R. & Hrvačić, B. (2009) Intranasal challenge with increasing ovalbumin doses differently affects airway hyperresponsiveness and inflammatory cell accumulation in mouse model of asthma.. Inflammation Research, 58 (11), 773-781.
@article{article, year = {2009}, pages = {773-781}, keywords = {allergen-induced airway hyperresponsiveness (AHR), asthma, BALF}, journal = {Inflammation Research}, volume = {58}, number = {11}, issn = {1023-3830}, title = {Intranasal challenge with increasing ovalbumin doses differently affects airway hyperresponsiveness and inflammatory cell accumulation in mouse model of asthma.}, keyword = {allergen-induced airway hyperresponsiveness (AHR), asthma, BALF} }
@article{article, year = {2009}, pages = {773-781}, keywords = {allergen-induced airway hyperresponsiveness (AHR), asthma, BALF}, journal = {Inflammation Research}, volume = {58}, number = {11}, issn = {1023-3830}, title = {Intranasal challenge with increasing ovalbumin doses differently affects airway hyperresponsiveness and inflammatory cell accumulation in mouse model of asthma.}, keyword = {allergen-induced airway hyperresponsiveness (AHR), asthma, BALF} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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