engleski

Cytogenetics and molekular findings in childhood leukemia of South Croatia

The aim of this study was to identify cytogenetic and molecular findings among the major pediatric leukemia in South Croatia. Leukemia is most common malignant disease in childhood and presents approximately 25% of all childhood cancer. This study showed the incidence of 3, 2 new cases of acute leukemia per 100000 children under the age of 18 years in our population. Immunophenotype characteristics of the 27(82%) pediatric patients with ALL and 6 patients with AML (18%) were analyzed. The most frequent abnormalities found in ALL were different abnormalities of chromosome short arm 9p (3/24 cases) and between AML it was t(8 ; 21)(q22 ; q22) (2/6). The most frequent gene rearangement was TEL/AML1 in 14/27 (51.5%) of all ALL cases. Due to the small number of patients in each genetic subgroup and short time of their follow-up, we could not analyze the relationship between the outcome and each gene rearrangement.

cytogenetics; molecular genetics; childhood; leukemia

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