engleski

Immunologic aspects of atopic dermatitis

Atopic dermatitis/eczema is a chronically relaps¬ ; ing, pruritic, and inflammatory skin disease. The term “ atopic eczema/dermatitis syndrome” covers the “ extrinsic” and “ intrinsic” atopic dermatitis. The pathogenesis of AD is a complex interaction between genetic background, skin barrier defects, abnormalities in innate and adaptive immunity, abnormalities of humoral and cellular immunity, and envi¬ ; ronmental influences. Understanding immunopathogenesis of atopic dermatitis lead to new diagnostic and therapeutic approaches. The targets in atopic dermatitis are innate immunity including improvement of skin barrier defects by supplementing lipids or inhibiting proteases, and regulating antimicrobial peptides, adaptive immunity, and induction of regulatory T cells.

Atopic dermatitis ; atopic eczema/dermatitis syndrome ; immunopathogenesis of AD ;

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