engleski

Detection of pregnancy methemoglobinemia with a fast, noninvasive, continuous and inexpensive method using Masimo pulsE co-oximeter Rainbow RAD57 - the result of the pilot study

The role of methemoglobin (MetHb) during pregnancy is often unrecognized and underemphasized by obstetricians. The confirmation of this is the lack of research concerning MetHb as the biomarker of adverse effects of oxidative stress and its prooxidant property. The aim of this epidemiological research is to evaluate a direct, new, noninvasive and continuous measurement which will facilitate the useful detection of potentially life-threatening acquired methemoglobinemia and risk pregnancy. Measurements were carried out on 346 women with complicated pregnancy, who were admitted to the Department of Fetomaternal Medicine at the University Hospital in Rijeka, Croatia during 2007. The admitted pregnant women were monitored with the new Masimo eight-wavelength Pulse Co-Oximeter Rainbow-Set Rad57 sensor. We set the limit of the normal level of maternal methemoglobin under or up to 1%, according to the quotations in recent literature. Measurements have shown that among 4 cases (1.16%) with 1% or more than 1% of MetHb, there was one case of stillbirth during the 30th week of pregnancy, which is statistically significant ( P= 0.0116) in relation to the pregnancies with the concentration of MetHb lower than 1%. Methemoglobinemia is a pervasive and significant clinical condition. Maternal mortality and perinatal loss are major unsolved problems, from the social, economical and medical point of view, particularly in underdeveloped countries. The ability of using the noninvasive, continuous and inexpensive method to evaluate MetHb enables this method to become a powerful diagnostic tool, when compared to the limited availability of current laboratory standard of measurement, the invasive CO-Oximetry.

methemoglobin; pregnancy

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