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Pregled bibliografske jedinice broj: 428499

Current approaches to the pharmacotherapy of opiate addiction


Sakoman, Slavko; Jernej, Branimir
Current approaches to the pharmacotherapy of opiate addiction // 3. croatian congress of neuroscience - abstract book
Zagreb, 2009. (poster, domaća recenzija, sažetak, znanstveni)


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Naslov
Current approaches to the pharmacotherapy of opiate addiction

Autori
Sakoman, Slavko ; Jernej, Branimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
3. croatian congress of neuroscience - abstract book / - Zagreb, 2009

Skup
The Third Croatian Congress of Neuroscience

Mjesto i datum
Zadar, Hrvatska, 24.-26.09.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
mu-receptor agonist; buprenorphine; opiate addiction

Sažetak
Partial agonists of neurotransmitter receptors, often called "stabilizers", act somewhere between full receptor aognists and silent receptor antagonist, theoretically boosting defficient but also inhibiting excessive neurotransmitter activity. Pharmacotherapy of opiate dependence, besides traditional substitution with methadone - the opioid mu-receptor full agonist (and possible adjuvant detoxification with opioid antagonist naltrexone) is currently oriented toward partial agonists of opioid receptors. Buprenorphine (Subutex) demonstrates partial mu-receptor agonism and seems a good alternative to methadone substitution in most cases of opiate addiction. Newer derivative of buprenorphine - Suboxone besides buprenorphine contains about 25% of opiate antagonist naloxone which prevents intravenous abuse. Results of recent clinical experience with administration of Subutex in opiate addiction will be presented and indications as well as contraindications for its use will be discussed.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
098-1081870-2395 - Serotonergična neurotransmisija: geni, proteini i ponašanje (Štefulj, Jasminka, MZOS ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Branimir Jernej (autor)

Avatar Url Slavko Sakoman (autor)


Citiraj ovu publikaciju:

Sakoman, Slavko; Jernej, Branimir
Current approaches to the pharmacotherapy of opiate addiction // 3. croatian congress of neuroscience - abstract book
Zagreb, 2009. (poster, domaća recenzija, sažetak, znanstveni)
Sakoman, S. & Jernej, B. (2009) Current approaches to the pharmacotherapy of opiate addiction. U: 3. croatian congress of neuroscience - abstract book.
@article{article, author = {Sakoman, Slavko and Jernej, Branimir}, year = {2009}, pages = {45}, keywords = {mu-receptor agonist, buprenorphine, opiate addiction}, title = {Current approaches to the pharmacotherapy of opiate addiction}, keyword = {mu-receptor agonist, buprenorphine, opiate addiction}, publisherplace = {Zadar, Hrvatska} }
@article{article, author = {Sakoman, Slavko and Jernej, Branimir}, year = {2009}, pages = {45}, keywords = {mu-receptor agonist, buprenorphine, opiate addiction}, title = {Current approaches to the pharmacotherapy of opiate addiction}, keyword = {mu-receptor agonist, buprenorphine, opiate addiction}, publisherplace = {Zadar, Hrvatska} }




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