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Pregled bibliografske jedinice broj: 428495

Synthesis and biological evaluation of O-methyl and O-ethyl NSAID hydroxamic acids


Rajić, Zrinka; Perković, Ivana; Butula, Ivan; Zorc, Branka; Hadjipavlou-Litina, Dimitra; Pontiki, Eleni; Pepeljnjak, Stjepan; Kosalec, Ivan
Synthesis and biological evaluation of O-methyl and O-ethyl NSAID hydroxamic acids // Journal of enzyme inhibition and medicinal chemistry, 24 (2009), 5; 1179-1187 doi:10.1080/14756360902779128 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 428495 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Synthesis and biological evaluation of O-methyl and O-ethyl NSAID hydroxamic acids

Autori
Rajić, Zrinka ; Perković, Ivana ; Butula, Ivan ; Zorc, Branka ; Hadjipavlou-Litina, Dimitra ; Pontiki, Eleni ; Pepeljnjak, Stjepan ; Kosalec, Ivan

Izvornik
Journal of enzyme inhibition and medicinal chemistry (1475-6366) 24 (2009), 5; 1179-1187

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
NSAID hydroxamic acids; antimicrobial activity; urease; antioxidant activity; soybean lipoxygenase; inhibition

Sažetak
This paper reports the synthesis of O-methyl and O-ethyl NSAID hydroxamic acids, their antimicrobial activities, and their ability to inhibit urease and soybean lipoxygenase activities. Ibuprofen and fenoprofen hydroxamic acids with free hydroxy groups present the highest antimicrobial activity, while indomethacin and diclofenac analogs show significantly lower antimicrobial activity. Diclofenac hydroxamic acid 4e exerts the highest antiurease activity. Indomethacin O-ethyl hydroxamic acid 3h and ibuprofen O-benzyl hydroxamic acid 4b exert significant inhibitory activities on soybean lipoxygenase. Fenoprofen and indomethacin O-ethyl hydroxamic acids 3b and 3h and diclofenac and indomethacin O-benzyl analogs 4g and 4i highly inhibit lipid peroxidation. The highest antioxidant activity was shown by fenoprofen derivative 3b.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija



POVEZANOST RADA


Projekt / tema
006-0061117-1242 - Mikromicete, interakcije toksičnih metabolita-zdravlje i prevencija (Maja Šegvić Klarić, )
006-0000000-3216 - Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari (Branka Zorc, )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Ivan Kosalec (autor)

Avatar Url Stjepan Pepeljnjak (autor)

Avatar Url Ivan Butula (autor)

Avatar Url Zrinka Rajić (autor)

Avatar Url Ivana Perković (autor)

Avatar Url Branka Zorc (autor)

Citiraj ovu publikaciju

Rajić, Zrinka; Perković, Ivana; Butula, Ivan; Zorc, Branka; Hadjipavlou-Litina, Dimitra; Pontiki, Eleni; Pepeljnjak, Stjepan; Kosalec, Ivan
Synthesis and biological evaluation of O-methyl and O-ethyl NSAID hydroxamic acids // Journal of enzyme inhibition and medicinal chemistry, 24 (2009), 5; 1179-1187 doi:10.1080/14756360902779128 (međunarodna recenzija, članak, znanstveni)
Rajić, Z., Perković, I., Butula, I., Zorc, B., Hadjipavlou-Litina, D., Pontiki, E., Pepeljnjak, S. & Kosalec, I. (2009) Synthesis and biological evaluation of O-methyl and O-ethyl NSAID hydroxamic acids. Journal of enzyme inhibition and medicinal chemistry, 24 (5), 1179-1187 doi:10.1080/14756360902779128.
@article{article, year = {2009}, pages = {1179-1187}, DOI = {10.1080/14756360902779128}, keywords = {NSAID hydroxamic acids, antimicrobial activity, urease, antioxidant activity, soybean lipoxygenase, inhibition}, journal = {Journal of enzyme inhibition and medicinal chemistry}, doi = {10.1080/14756360902779128}, volume = {24}, number = {5}, issn = {1475-6366}, title = {Synthesis and biological evaluation of O-methyl and O-ethyl NSAID hydroxamic acids}, keyword = {NSAID hydroxamic acids, antimicrobial activity, urease, antioxidant activity, soybean lipoxygenase, inhibition} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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