engleski

HLA class II risk alleles in Croatian patients with pemphigus vulgaris

Pemphigus vulgaris is autoimmune blistering disease caused by autoantibodies against keratinocyte adhesion molecules desmoglein 3 and 1. It is widely accepted that pemphigus vulgaris (PV) is HLA associated disease. We started a prospective study of association of HLA class II alleles and haplotypes in patients with pemphigus in Croatia. During last 12 months we were performed a pilot study of HLA genotyping in 12 patients with PV and compared results with control group of blood donors at Croatian institute of transfusion medicine. HLA typing was performed using high resolution PCR-SSP method (Olerup- SSP, Qiagen, Germany) In our results we observed high frequency of DRB1*0402 (AF 0.375) , DQB1*0302 (AF 0.375) and DQA1*030101 (AF 0.333). Frequency of these alleles is significanty higher than in control group (AF 0.018 ; 0.061 ; 0.245 respectively). Frequency of associated haplotype DRB1*0402-DQA1*030101- DQB1*0302 is 0.25 vs. 0.020 in control group. Most of presented patients are from central part of Croatia. In our prospective study we will also focus on patiens from Mediterranean part of Croatia (patients from along a cost of Adriatic see) in which, acording to first results we could expect completely different HLA class II alleles.

Pemphigus vulgaris; HLA associated disease; HLA class II alleles

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