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Pregled bibliografske jedinice broj: 427553

Antioxidative and vasodilatory effects of phenolic acids in wine


Mudnić, Ivana; Modun, Darko; Rastija, Vesna; Vuković, Jonatan; Brizić, Ivan; Katalinić, Višnja; Kozina, Bernard; Medić-Šarić, Marica; Boban, Mladen
Antioxidative and vasodilatory effects of phenolic acids in wine // Food chemistry, 119 (2010), 3; 1205-1210 doi:10.1016/j.foodchem.2009.08.038 (međunarodna recenzija, članak, znanstveni)


Naslov
Antioxidative and vasodilatory effects of phenolic acids in wine

Autori
Mudnić, Ivana ; Modun, Darko ; Rastija, Vesna ; Vuković, Jonatan ; Brizić, Ivan ; Katalinić, Višnja ; Kozina, Bernard ; Medić-Šarić, Marica ; Boban, Mladen

Izvornik
Food chemistry (0308-8146) 119 (2010), 3; 1205-1210

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Phenolic acids; Vasodilation; Antioxidative activity; Wine; Quantitative structure activity relationship

Sažetak
Phenolic acids represent important fraction of wine phenolics, but their biological effects have been scarcely investigated. We examined interrelationship between antioxidative capacity and vasodilatory activity, two potentially beneficial biological effects, of 9 phenolic acids from wine. The observed antioxidative and vasodilatory effects of the tested phenolic acids were further evaluated through quantitative structure-activity relationship (QSAR) analysis, by using molecular properties, “ two-dimensional” (2D) and “ three-dimensional” (3D) molecular descriptors. The antioxidative capacity of phenolic acids was measured by Ferric Reducing Antioxidant Power (FRAP) and Trolox Equivalent Antioxidant Capacity (TEAC) methods whereas their vasodilatory activity was determined in the precontracted rat aortic rings. FRAP and TEAC values for antioxidative capacity positively correlated, but antioxidative capacity and maximal vasodilatory effect of the acids showed a negative correlation. This was best illustrated by poor vasodilatory activity of gallic acid, which is the strongest antioxidant among the tested phenolic acids. QSAR study described how antioxidative and vasodilatory effects of phenolic acids relate to number of hydroxyl groups in the phenyl ring, degree of compactness and branching of molecules, and three-dimensional distributions of atomic polarizability of the tested molecules.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Prehrambena tehnologija



POVEZANOST RADA


Projekt / tema
006-0061117-1237 - Biološki aktivni spojevi, metaboliti i QSAR (Marica Medić-Šarić, )
011-2160547-2226 - Prirodni izvori resveratrola i njegov sinergijski učinak s drugim polifenolima (Višnja Katalinić, )
216-2160547-0537 - Kardiovaskularni učinci vina i njegovih sastojaka (Mladen Boban, )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Kemijsko-tehnološki fakultet, Split,
Medicinski fakultet, Split

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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