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3-HYDROXY-2-METHYL-1-(p-AMINOPHENYL)-4-PYRIDONE AND ITS ROLE AS COMPLEXING AGENT


Car, Željka; Gojmerac Ivšić, Astrid; Tomić, Srđanka
3-HYDROXY-2-METHYL-1-(p-AMINOPHENYL)-4-PYRIDONE AND ITS ROLE AS COMPLEXING AGENT // Euroanalysis 2009
Insbruck, Austrija, 2009. (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
3-HYDROXY-2-METHYL-1-(p-AMINOPHENYL)-4-PYRIDONE AND ITS ROLE AS COMPLEXING AGENT

Autori
Car, Željka ; Gojmerac Ivšić, Astrid ; Tomić, Srđanka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
Euroanalysis 2009

Mjesto i datum
Insbruck, Austrija, 06.-10.09.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Pyridone detivatives

Sažetak
4-Pyridone derivatives are excellent complexing agents and therefore can be used in the extraction and spectrophotometric determination of metal ions.[1] Some pyridone derivatives are inhibitors of bacterial enzymes [2] and are potential antibacterial agents used for bacterial infections. Numerous spectrophotometric methods, especially the more sensitive ones, are based on the formation of the complexes between the chelating reagents and metal ions. The analytical application of few 3-hydroxy-4-pyridones has been outlined in the preceding communications. [3] Recently, there has been a significant interest in these compounds as sequestering agents for various metal ions. In this work we have explored the application of the new synthesized 4-pyridone derivative 3-hydroxy-2-methyl-1-(p-aminophenyl)-4-pyridone (HZ) as a complexing agent for different metal ions in aqueous solution, as well as the possibility of the extraction of formed complexes in organic phase. Due to high metal chelating affinity HZ has potential pharmacological usefulness, mostly related to removal therapies of unbalanced methal ions in the human body. 1] K. Jakopčić, B. Tamhina, F. Zorko, M. J. Herak, J. Inorg. Nucl. Chem. 39 (1977) 1201-1203. [2] H. Kitagawa, K. Kumura, S. Takahata, M. Iida, K. Atsumi, Bioorg. Med. Chem. 15 (2007) 1106-1116. [3] V. Vojković, A. Gojmerac Ivšić, B. Tamhina, Solv. Extr. Ion Exch. 14 (1996) 479-490. ; A. Gojmerac Ivšić, B. Tamhina, Talanta 38 (1991) 1403- 1407. ; B. Tamhina, A. Gojmerac Ivšić, Solv. Extr. Ion Exch. 5 (1987) 909-922.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
119-1191342-2959 - Spektroskopska analiza nezasićenih sustava i spojeva metala (Snežana Miljanić, )
119-1191344-3121 - Sinteze i enzimske transformacije biološki aktivnih spojeva (Srđanka Tomić-Pisarović, )

Ustanove
Prirodoslovno-matematički fakultet, Zagreb