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Synthesis and characterization of thiosemicarbazonato molybdenum(VI) complexes and their in vitro antitumor activity


Vrdoljak, Višnja; Đilović, Ivica; Rubčić, Mirta; Kraljević Pavelić, Sandra; Kralj, Marijeta; Matković-Čalogović, Dubravka; Piantanida, Ivo; Novak, Predrag; Rožman, Andrea; Cindrić, Marina
Synthesis and characterization of thiosemicarbazonato molybdenum(VI) complexes and their in vitro antitumor activity // European Journal of Medicinal Chemistry, 45 (2010), 1; 38-48 doi:10.1016/j.ejmech.2009.09.021 (međunarodna recenzija, članak, znanstveni)


Naslov
Synthesis and characterization of thiosemicarbazonato molybdenum(VI) complexes and their in vitro antitumor activity

Autori
Vrdoljak, Višnja ; Đilović, Ivica ; Rubčić, Mirta ; Kraljević Pavelić, Sandra ; Kralj, Marijeta ; Matković-Čalogović, Dubravka ; Piantanida, Ivo ; Novak, Predrag ; Rožman, Andrea ; Cindrić, Marina

Izvornik
European Journal of Medicinal Chemistry (0223-5234) 45 (2010), 1; 38-48

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Thiosemicarbazone; molybdenum(VI) complexes; X-ray crystal structures; antiproliferative effects; tumour cell lines

Sažetak
New dioxomolybdenum(VI) complexes were obtained by the reaction of [MoO2(acac)2] with thiosemicarbazone ligands derived from 3-thiosemicarbazide and 4-(diethylamino)salicylaldehyde (H2L1), 2-hydroxy-3-methoxybenzaldehyde (H2L2) or 2-hydroxy-1-naphthaldehyde (H2L3). In all complexes thiosemicarbazonato ligands are coordinated to molybdenum as tridentate ONS-donors. Octahedral coordination of each molybdenum atom is completed by methanol molecule (in 1a-3a) or by oxygen atom of Mo=O unit from the neighbouring molecule (in 1-3). All complexes were characterized by means of chemical analyses, IR spectroscopy, TG and NMR measurements. The molecular structures of the ligand H2L2 and complex [MoO2L2(CH3OH)]• CH3OH (2a) have been determined by single crystal X-ray crystallography. The characterisation of thiosemicarbazonato molybdenum(VI) complexes (1-4) as well as of the 4-phenylthisemicarbazonato molybdenum(VI) complexes (5-8) in aqueous medium revealed that upon dissolving complexes in water, most likely to some extent dissociation took place, although experimental data didn’ t allow exact quantification of dissociation. The antiproliferative effects of studied molybdenum(VI) complexes (1-8) on the human cell lines were identical to the activity of their corresponding ligands.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2514 - Uloga različitih mehanizama odgovora stanica na terapiju oštećenjem DNA (Marijeta Kralj, )
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Ivo Piantanida, )
119-1191342-1082 - Novi kompleksni spojevi i materijali-kemijski i biološki katalizatori (Marina Cindrić, )
119-1191342-1083 - Interakcije i dizajn bioaktivnih molekula (Predrag Novak, )
119-1193079-1084 - Strukturno istraživanje bioloških makromolekula metodom rentgenske difrakcije (Dubravka Matković-Čalogović, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • MEDLINE


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