Synthesis and characterization of thiosemicarbazonato molybdenum(VI) complexes and their in vitro antitumor activity (CROSBI ID 155451)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Vrdoljak, Višnja ; Đilović, Ivica ; Rubčić, Mirta ; Kraljević Pavelić, Sandra ; Kralj, Marijeta ; Matković-Čalogović, Dubravka ; Piantanida, Ivo ; Novak, Predrag ; Rožman, Andrea ; Cindrić, Marina
engleski
Synthesis and characterization of thiosemicarbazonato molybdenum(VI) complexes and their in vitro antitumor activity
New dioxomolybdenum(VI) complexes were obtained by the reaction of [MoO2(acac)2] with thiosemicarbazone ligands derived from 3-thiosemicarbazide and 4-(diethylamino)salicylaldehyde (H2L1), 2-hydroxy-3-methoxybenzaldehyde (H2L2) or 2-hydroxy-1-naphthaldehyde (H2L3). In all complexes thiosemicarbazonato ligands are coordinated to molybdenum as tridentate ONS-donors. Octahedral coordination of each molybdenum atom is completed by methanol molecule (in 1a-3a) or by oxygen atom of Mo=O unit from the neighbouring molecule (in 1-3). All complexes were characterized by means of chemical analyses, IR spectroscopy, TG and NMR measurements. The molecular structures of the ligand H2L2 and complex [MoO2L2(CH3OH)]• CH3OH (2a) have been determined by single crystal X-ray crystallography. The characterisation of thiosemicarbazonato molybdenum(VI) complexes (1-4) as well as of the 4-phenylthisemicarbazonato molybdenum(VI) complexes (5-8) in aqueous medium revealed that upon dissolving complexes in water, most likely to some extent dissociation took place, although experimental data didn’ t allow exact quantification of dissociation. The antiproliferative effects of studied molybdenum(VI) complexes (1-8) on the human cell lines were identical to the activity of their corresponding ligands.
thiosemicarbazone ; molybdenum(VI) complexes ; X-ray crystal structures ; antiproliferative effects ; tumour cell lines
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Podaci o izdanju
45 (1)
2010.
38-48
objavljeno
0223-5234
1768-3254
10.1016/j.ejmech.2009.09.021
Povezanost rada
Kemija, Temeljne medicinske znanosti