Increased expression of tumor necrosis factor-related apoptosis inducing ligand and its receptors in lichen planus lesions (CROSBI ID 554510)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Peternel, Sandra ; Kaštelan, Marija ; Prpić-Massari, Larisa ; Kurilić, Marijana
engleski
Increased expression of tumor necrosis factor-related apoptosis inducing ligand and its receptors in lichen planus lesions
The hallmark pathohistological change in lichen planus lesions is damage to the epidermal basal layer, considered to be mediated by dermal mononuclear cell inflammatory infiltrate. The purpose of our study was to investigate whether this damage might be mediated by tumor necrosis factor-related apoptosis inducing ligand (TRAIL) and its two death receptors TRAIL-R1 (DR4) and TRAIL-R2 (DR5). The pattern of tissue expression of TRAIL and its receptors was analyzed by immunohistochemical analysis performed on lesional skin samples of patients with lichen planus as well as skin samples of healthy volunteers. TRAIL and both of its receptors were found to be strongly expressed among cells comprising the dermal infiltrate in lesional skin. The epidermal expression of TRAIL was only slightly increased in lichen planus lesions when compared to healthy skin. Interestingly, a significantly stronger expression of DR4 and DR5 was observed in the epidermal basal layer of lichen planus lesions when compared to healthy skin in which the expression was low or even absent. These results indicate that TRAIL/DR4/DR5 -mediated signalling might be involved in the pathogenesis of lichen planus, especially in the basal cell layer degeneration typical of this dermatosis.
lichen planus; TNF-related apoptosis-inducing ligand; Death receptor 4; Death receptor 5
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Podaci o prilogu
S95-x.
2009.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Journal of investigative dermatology
Nature publishing group
0022-202X
Podaci o skupu
39th Annual ESDR Meeting
poster
09.09.2009-12.09.2009
Budimpešta, Mađarska
Povezanost rada
Temeljne medicinske znanosti, Kliničke medicinske znanosti