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Genotoxic effect of quercetin/lanthnum complex on human cervical carcinoma cells


Durgo, Ksenija; Kopjar, Nevenka; Halec, Ivana; Rusak, Gordana; Franekić Čolić; Jasna
Genotoxic effect of quercetin/lanthnum complex on human cervical carcinoma cells // Program and Abstract Book, 10 th International Conference on Environmental Mutagens
Firenze, 2009. str. 263-263 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Genotoxic effect of quercetin/lanthnum complex on human cervical carcinoma cells

Autori
Durgo, Ksenija ; Kopjar, Nevenka ; Halec, Ivana ; Rusak, Gordana ; Franekić Čolić ; Jasna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Program and Abstract Book, 10 th International Conference on Environmental Mutagens / - Firenze, 2009, 263-263

Skup
10 th International Conference on Environmental Mutagens

Mjesto i datum
Firenca, Italija, 20-25.08.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Citotoxicity; neutral red assay; comet assay; quercetin/lanthanum complex

Sažetak
Quercetin is the main flavonoid present in our diet. Because of its specific chemical and biological properties, quercetin has been one of the most studied flavonoids for potential cardiovascular, neurodegenerative diseases and cancer treatments. Quercetin readily forms chelates with metal ions as a result of specific chemical structure. The aim of this study was to evaluate potential genotoxic effect of quercetin/lanthanum complex on human cervical carcinoma cells. First the influence of physiological solution on cells viability was investigated due to it's instability in physiological conditions and stability in isotonic solution of sodium chloride. Investigated complex showed considerable cytotoxicity within 100-1000 μ M concentration during 3 hours of the cells exposure. Also, complex showed dose/response depended prooxidant activity and induction of single strand and double strand breaks of DNA. If future experiments show selectively effects of quercetin/lanthanum complex to cancer cells and it's stability in physiological conditions, it can be used in treating patients.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Biotehnologija



POVEZANOST RADA


Projekt / tema
022-0222148-2137 - Genotoksičnost kemijskih i fizikalnih agensa prirodnog i antropogenog podrijetla (Vilena Kašuba, )
058-0582261-2246 - Utjecaj mutagena i antimutagena na molekularne procese u stanici (Reno Hrašćan, )
119-1191192-1213 - Flavonoidi i molekularni mehanizmi njihovih bioloških učinaka (Gordana Rusak, )

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Prehrambeno-biotehnološki fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb