engleski

Blood volume changes after long-term correction of anemia with recombinant human erythropoietin(EPO)in patients on maintenance hemodialysis

The purpose of this study was to evaluate blood volume changes in chronic hemodialysis patients after long-term correction of anemia with recombinant human erythropoietin(EPO). Twenty three patients(12 males, 11 females, mean age 38+/-10 years) with severe renal anemia(hematocrit<0, 25) and on hemodialysis(mean duration 5.8+/- 3.7 years) were studied: 1)basally, before EPO treatment ; 2)short-term, at the time when target hemoglobin(Hg) reached 100g/l ; and 3)long-term, after 12 months of therapy.Blood volume was measured with Tc-99m-labeled human serum albumin using the method adjusted and validated in our laboratory.

blood volume; anemia; recombinant human erythropoietin(EPO); hemodialysis

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