RNA Interference as a New Tool in Therapeutics (CROSBI ID 155246)
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Podaci o odgovornosti
Matokanović, Mirela ; Barišić, Karmela
engleski
RNA Interference as a New Tool in Therapeutics
The basic principle of RNA interference, a possible new therapeutic tool, involves destruction of messenger RNA upon interaction with homologous double-stranded RNA present in the cell cytoplasm. Studies have shown that both viral and non-viral small interfering RNA delivery methods and delivery of chemically synthesized small interfering RNAs to the cell can provide selective gene suppression through this mechanism, both in vitro and in vivo. Before becoming a functional therapeutic tool, there are a number of problems concerning RNA interference that should be solved. Major problems involve off- -target effects, insertional mutagenesis and malignant transformation, as well as problems of delivery methods and reduction of toxicity.
RNA interference; small interfering RNA; off-target effects; therapeutics
Odabrani radovi sa skupa Congress of Croatian Society of Biochemistry and Molecular Biology, održanog od 17.-20.09.2008.g., Osijek, Hrvatska.
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