Napredna pretraga

Pregled bibliografske jedinice broj: 425064

Evaluation of radioprotective effects of propolis and its flavonoid constituents: in vitro study on human white blood cells


Benković, Vesna; Horvat Knežević, Anica; Oršolić, Nada; Bašić, Ivan; Ramić, Snježana; Viculin, Tomislav; Knežević, Fabijan; Kopjar, Nevenka
Evaluation of radioprotective effects of propolis and its flavonoid constituents: in vitro study on human white blood cells // Phytoherapy Research, 23 (2009), 8; 1159-1168 doi:10.1002 (međunarodna recenzija, članak, znanstveni)


Naslov
Evaluation of radioprotective effects of propolis and its flavonoid constituents: in vitro study on human white blood cells

Autori
Benković, Vesna ; Horvat Knežević, Anica ; Oršolić, Nada ; Bašić, Ivan ; Ramić, Snježana ; Viculin, Tomislav ; Knežević, Fabijan ; Kopjar, Nevenka

Izvornik
Phytoherapy Research (0951-418X) 23 (2009), 8; 1159-1168

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Propolis; flavonoids; radioprotection; in vitro; leukocytes

Sažetak
This in vitro study aims at evaluating the possible radioprotective effects of natural substances WSDP, caffeic acid, chrysin and naringin on γ -irradiated human white blood cells. The effectiveness of tested compounds was evaluated using the alkaline comet assay, the analysis of structural chromosome abberation and cytokinesis-block micronucleus assay. The results obtained by alkaline comet study indicate favorable toxicity profiles of propolis and its polyphenolic components, and confirmed radioprotective abilities comparable with chemical radioprotector AET. WSDP and its polyphenolic components were able to reduce the number of necrotic cells. None of tested compounds induced significant genotoxicity evens all of them offered a quite measurable protection against DNA damage. WSDP was found to be most effective in diminishing the levels of primary and more complex cytogenetic DNA damage in white blood cells. Considering its complex composition, to undoubtedly explain the underlying mechanisms of cyto/radioprotective effects, further studies are needed.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA


Projekt / tema
022-0222148-2137 - Genotoksičnost kemijskih i fizikalnih agensa prirodnog i antropogenog podrijetla (Vilena Kašuba, )
119-0000000-1255 - Kemoprevencija rasta tumora polifenolnim sastavnicama (Nada Oršolić, )
119-0532265-1254 - Imunoadjuvantno i zaštitno djelovanje propolisa u životinja (Vesna Benković, )

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • EMBASE (Excerpta Medica)


Citati