engleski

Plant Hormones Auxins Disturbe Cell Cycle of Human Tumor Cells

Phytohormones auxins are the key regulators of plant growth and development. Recently, it has been shown that they regulate transcription of plant genes by targeting transcriptional repressor IAA/AUX to degradation. While there are many reports describing their potential to modulate human cell functions, the majority is based on auxin action following enzymatic activation. The here-presented study is focused on auxins alone and their antiproliferative potential, with emphasis on the modulation of the cell cycle. Therefore, the tumor growth inhibitory effect and the cell cycle perturbations of natural (IAA, IBA) and synthetic (NAA, 2, 4-D) auxins were analyzed. All derivatives showed cytostatic effect on selected human tumor cell lines. The cell cycle analysis revealed that IAA and 2, 4-D induce strong G1 arrest, along with drastic decrease of S phase-cells percentage in MCF-7 cell line. The observed effect points that auxins may have a novel, unexploited antitumor potential, and should be further investigated in this regard.

IAA; IBA; NAA; 2; 4-D; human tumor cells; G1 arrest

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