engleski

Halo phenomenon with regression of acquired melanocytic nevi- a case report.

Background: Halo nevi demonstrate dense lymphocytic infiltrates that permeate a portion of or all the neoplasm. Depigmented area around those nevi is clinically usually but not always seen. Halo represents immunologic reaction mediated with T or B lymphocytes against melanocytic antigens. Aim: To demonstrate the case with relatively rare nevi with halo phenomenon and to show the clinical and histological difficulties in the diagnosis establishment. Case report: A 19-year old girl with two symptomless erythematous papules at the left breast that appeared 6-years ago. The personal and family history for diseases in association with halo nevi was negative. In last two years solarium was used 4 times a year ; in childhood she experienced sunburns. Methods: The halo was seen neither clinically nor with Wood lamp. Dermoscopy revealed erythematous homogenous pattern and at the periphery brown streaks. Histology of the lesion in upper lateral quadrant revealed in upper dermis dense lichenoid infiltrates of mononuclears and fibroplasias, at the periphery at the epidermal/dermal junction rare nests. The staining with HMB 45 was positive exclusively at epidermal/dermal junction. In the perimammillary lesion there were single melanocytes and rare nests at the epidermal/dermal junction with medium infiltrate of lymphocytes and histiocytes. The histological diagnosis in both cases was melanocytic junctional nevus with halo phenomena. Conclusion: Halo nevus is not a single clinicopathological entity. In advanced stage of regression with almost completely destroyed melanocytes, clinical and dermatoscopic diagnosis of melanocytic lesion is impossible, while histological diagnosis is also hard if melanocytes are completely missing.

Halo phenomenon; acquired melanocytic nevi; case report

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