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Pregled bibliografske jedinice broj: 42287

Ferrocenes (F168, F169) and ferric-sorbital-citrate (FCS) : Potential anticancer drugs


Ferle-Vidović, Ana; Poljak-Blaži, Marija; Rapić, Vladimir; Škare, Danko
Ferrocenes (F168, F169) and ferric-sorbital-citrate (FCS) : Potential anticancer drugs // Cancer biotherapy & radiopharmaceuticals, 15 (2000), 617-624 (međunarodna recenzija, članak, znanstveni)


Naslov
Ferrocenes (F168, F169) and ferric-sorbital-citrate (FCS) : Potential anticancer drugs

Autori
Ferle-Vidović, Ana ; Poljak-Blaži, Marija ; Rapić, Vladimir ; Škare, Danko

Izvornik
Cancer biotherapy & radiopharmaceuticals (1084-9785) 15 (2000); 617-624

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ferrocenes; ferric sorbitol citrate; iron; growth modulation; cell viability; tumor cell lines

Sažetak
We have shown earlier that the iron containing, ferric-sorbitol-citrate complex (FSC) inhibited proliferation of cultured mouse melanoma B16, GHC, KB, HeLa and CaCo2 cells and caused mouse melanoma regression in vivo. This drug did not affect the proliferation of the nonmalignant fibroblast L929 line, human bone marrow - HBS, VERO and HEF cell line. It is also known, that some metallocene derivatives posses antitumour properties resulting principally from their action on the metabolism of DNA, and subsequently, RNA and proteins. We synthesized in our laboratory some ferrocene analogs (F168 and F169) and tested their antiproliferative ability for malignant human carcinoma Hep2 and mouse melanoma F10 cell lines. As control cell lines, human HEF and mice L929 fibroblasts were used. The tested iron substances were very potent in inhibiting the growth of malignant cell lines, whereas they had no significant inhibitory effect on the viability of nonmalignant fibroblasts. The most pronounced growth inhibitory and cytotoxic effect was found in the malignant F10 cells and the most potent was ferrocene F169. Because of their selective effect on malignant cells, the ferric-sorbitol-citrate complex as well as tested ferrocenes will be further investigated and submitted as new antitumour substances.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA


Ustanove
Prehrambeno-biotehnološki fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Ferle-Vidović, Ana; Poljak-Blaži, Marija; Rapić, Vladimir; Škare, Danko
Ferrocenes (F168, F169) and ferric-sorbital-citrate (FCS) : Potential anticancer drugs // Cancer biotherapy & radiopharmaceuticals, 15 (2000), 617-624 (međunarodna recenzija, članak, znanstveni)
Ferle-Vidović, A., Poljak-Blaži, M., Rapić, V. & Škare, D. (2000) Ferrocenes (F168, F169) and ferric-sorbital-citrate (FCS) : Potential anticancer drugs. Cancer biotherapy & radiopharmaceuticals, 15, 617-624.
@article{article, year = {2000}, pages = {617-624}, keywords = {ferrocenes, ferric sorbitol citrate, iron, growth modulation, cell viability, tumor cell lines}, journal = {Cancer biotherapy and \#38; radiopharmaceuticals}, volume = {15}, issn = {1084-9785}, title = {Ferrocenes (F168, F169) and ferric-sorbital-citrate (FCS) : Potential anticancer drugs}, keyword = {ferrocenes, ferric sorbitol citrate, iron, growth modulation, cell viability, tumor cell lines} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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