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Pregled bibliografske jedinice broj: 422503

Hsp70, TNFalpha and hsp32 gene polymorphisms and COPD


Matokanović, Mirela; Malić, Ana; Turk, Ana; Čepelak, Ivana; Popović-Grle, Sanja; Barišić, Karmela
Hsp70, TNFalpha and hsp32 gene polymorphisms and COPD // The FEBS Journal. 276, Supplement 1 (2009), Abstracts of the 34th FEBS Congress
Prague, Czech Republic: Wiley-Blackwell, 2009. str. 327-327 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 422503 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Hsp70, TNFalpha and hsp32 gene polymorphisms and COPD

Autori
Matokanović, Mirela ; Malić, Ana ; Turk, Ana ; Čepelak, Ivana ; Popović-Grle, Sanja ; Barišić, Karmela

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The FEBS Journal. 276, Supplement 1 (2009), Abstracts of the 34th FEBS Congress / - : Wiley-Blackwell, 2009, 327-327

Skup
34th FEBS Congress, Life's Molecular Interactions

Mjesto i datum
Prague, Czech Republic, 4-9 July 2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Hsp70-2; hsp70-hom; TNFα; hsp32; polymorphism; COPD

Sažetak
Genes encoding members of the heat shock protein (Hsp) 70 family, hsp70-1, hsp70-2 and hsp-hom, and gene encoding tumor necrosis factor alpha (TNFα ) lie in the class III region of the human major histocompatibility complex (MHC). Hsp70-1 and hsp70-2 genes encode the major heat and stress inducible Hsp70. Hsp70-hom encodes a protein that is highly related to Hsp70-1, but is not heat inducible. TNFα encodes pro-inflammatory cytokine, which plays an important role in inflammatory processes. Hsp32 gene (HOX-1) encodes inducible heme oxygenase-1, enzyme that catalyzes the degradation of heme, providing cellular protection against oxidative mediated injury. Polymorphisms of stress (hsp70 family and hsp32) and tumor necrosis factor alpha (TNFα ) genes have been reported to be related to chronic obstructive pulmonary disease (COPD), a disease associated with an immune as well as an oxidant/anti-oxidant imbalance. Therefore hsp70-2 A/G (+ 1267), hsp70-hom T/C (+ 2437) and TNFα G/A (+489) gene polymorphisms were analysed in patients with COPD by PCR-RFLP procedure. Polymorphisms of the HOX-1 gene regarding to the number of GT repeats in 5’ -flanking region were analysed with sequencing of PCR products. The obtained data showed that there were no statistically significant differences in the genotype distributions of hsp70-2 (Chi square test, P = 0, 186), hsp70-hom (Chi square test, P = 0, 859) and TNFα (Chi square test, P = 0, 299) between patients (31) with COPD and control subjects (48). Likewise there was no statistically significant difference in number of GT repeats in HOX-1 gene between patients with COPD and control subjects (Chi square test, P = 0, 907).

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
006-0061117-1236 - Posttranskripcijsko utišavanje stresnih proteina pomoću siRNA nanoterapije (Barišić, Karmela, MZOS ) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb


Citiraj ovu publikaciju:

Matokanović, Mirela; Malić, Ana; Turk, Ana; Čepelak, Ivana; Popović-Grle, Sanja; Barišić, Karmela
Hsp70, TNFalpha and hsp32 gene polymorphisms and COPD // The FEBS Journal. 276, Supplement 1 (2009), Abstracts of the 34th FEBS Congress
Prague, Czech Republic: Wiley-Blackwell, 2009. str. 327-327 (poster, međunarodna recenzija, sažetak, znanstveni)
Matokanović, M., Malić, A., Turk, A., Čepelak, I., Popović-Grle, S. & Barišić, K. (2009) Hsp70, TNFalpha and hsp32 gene polymorphisms and COPD. U: The FEBS Journal. 276, Supplement 1 (2009), Abstracts of the 34th FEBS Congress.
@article{article, author = {Matokanovi\'{c}, Mirela and Mali\'{c}, Ana and Turk, Ana and \v{C}epelak, Ivana and Popovi\'{c}-Grle, Sanja and Bari\v{s}i\'{c}, Karmela}, year = {2009}, pages = {327-327}, keywords = {Hsp70-2, hsp70-hom, TNFα, hsp32, polymorphism, COPD}, title = {Hsp70, TNFalpha and hsp32 gene polymorphisms and COPD}, keyword = {Hsp70-2, hsp70-hom, TNFα, hsp32, polymorphism, COPD}, publisher = {Wiley-Blackwell}, publisherplace = {Prague, Czech Republic} }
@article{article, author = {Matokanovi\'{c}, Mirela and Mali\'{c}, Ana and Turk, Ana and \v{C}epelak, Ivana and Popovi\'{c}-Grle, Sanja and Bari\v{s}i\'{c}, Karmela}, year = {2009}, pages = {327-327}, keywords = {Hsp70-2, hsp70-hom, TNFα, hsp32, polymorphism, COPD}, title = {Hsp70, TNFalpha and hsp32 gene polymorphisms and COPD}, keyword = {Hsp70-2, hsp70-hom, TNFα, hsp32, polymorphism, COPD}, publisher = {Wiley-Blackwell}, publisherplace = {Prague, Czech Republic} }




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