engleski

Pharmacologic Characterization of Latex Extract by Isolated Guinea Pig Tracheal Tissue

The effetc of latex extracts on isolated guinea pig thracheal smooth muscles was studied using latex wate-soluble extracts obtained at different stages of the industrial process.Dose-related contractions of nonsensitized guinea pig trachea were demostrated.Constrictor effects of the dust extracts were inhibited by atropine.This observation may suggest and interaction of the extracts with parasympathetic nerves or more directly with muscarinic receptors. We suggest that latex extracts cause dose-related airway smooth muscle constriction by nonimmunological mechanisms involving a variety of airway mediators and possibly cholinergic receptors.

Latex extract; Airway smooth muscle; Respiratory symptoms

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