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Earthworms as a source of bioactive molecules

Grdiša, Mirica; Mikecin, Ana-Matea; Hrženjak, Mihaela-Terezija
Earthworms as a source of bioactive molecules // Current Bioactive Compounds, 5 (2009), 2; 155-159 doi:10.2174/157340709788451957 (međunarodna recenzija, pregledni rad, znanstveni)

Earthworms as a source of bioactive molecules

Grdiša, Mirica ; Mikecin, Ana-Matea ; Hrženjak, Mihaela-Terezija

Current Bioactive Compounds (1573-4072) 5 (2009), 2; 155-159

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Eisenia foetida ; G-90 ; earthworms ; bioactive molecules

Searching for bioactive molecules from natural source represents an attractive strategy. Natural bioactive molecules form the backbone of modern therapeutics. For that reason the glycolipoprotein extract (G-90) from tissue homogenate of earthworm Eisenia foetida represents a valuable source of bioactive molecules. The molecules in this preparation exhibit many biological characteristics, useful in different biological processes. This extract showed interaction with biological materials from evolutionary more developed species, such as serums, erythrocytes, normal and transformed cells in culture from different origin. The numerous biological activities in vitro and in vivo, such as mitogenicity, anticoagulation, fibrinolysis, bacteriostasis, antioxidation, were detected in G-90. In therapeutic concentrations G-90 was not toxic, allergenic, mutagen or carcinogen. G-90 protected cells in culture from oxidative damage, caused by hydrogen peroxide. It is capable to stimulate the cellular immune system. As fibrinolytic and anticoagulative agent it can participate in active maintenance of homeostasis. G-90 has the ability to stimulate the synthesis of growth factors and helps in tissue regeneration. It stimulates proliferation of fibroblasts and epithelial cells, as well as their differentiation. Accordingly, G-90 is a valuable mixture of bioactive molecules from natural source, which could be very useful in human and veterinary medicine.

Izvorni jezik

Znanstvena područja
Biologija, Temeljne medicinske znanosti


Projekt / tema
098-0982464-2393 - Molekularna obilježja miofibroblasta Dupuytrenove bolesti (Krešimir Pavelić, )

Institut "Ruđer Bošković", Zagreb

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