engleski

Absolute stereochemistry of alloxanic acid. A configurational relay for uricase reaction

Alloxanic acid was resolved by means of brucine and converted into its enantiomorphic esters and amides, ethyl(-)-alloxanate whose absolute (S)-configuration was established by X-ray analysis served as configurational standard for the correlation of (+)-(R)-alloxanic acid and its precursor (-)-(S)-5-hydroxyisourate, the key uricolytic intermediate.

alloxanic acid ; enantiomorphic esters ; X-ray ; (+)-(R)-alloxanic acid ; (-)-(S)-5-hydroxyisourate ; conversion ; mechanism ; allantoin

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