Tracing and identification of uricase reaction intermediates. A direct 13C-NMR/isotope-labelling evidence (CROSBI ID 154264)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Modrić, Nevenka ; Derome, A.E. ; Ashcroft, S.J.H. ; Poje, Mirko
engleski
Tracing and identification of uricase reaction intermediates. A direct 13C-NMR/isotope-labelling evidence
The C-13-NMR spectra are characteristic and provide the pathway of uricase-catalysed oxidation of [5-C-13]urate to [4-C-13]allantoin ; 5-hydroxy[5-C-13]isouric acid, its ring-opened derivative 3 and [4-C-13]allantoin-5-carboxylate were identified as consecutive intermediates in D2O/phosphate buffer (pD 7.2).
mechanism ; conversion ; allantoin ; urate ; 5-hydroxy[5-C-13]isouric acid
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Podaci o izdanju
33 (44)
1992.
6691-6694
objavljeno
0040-4039
1873-3581
10.1016/S0040-4039(00)61021-3