engleski

Growth and Biosynthesis of Aflatoxin in Presence of Newly Synthesized Analogues of Dehydroacetic Acid

Mycelial growth and toxin accumulation by Aspergillus flavus were inhibited by dehydroacetic acid (DHA) and its newly synthesized analogues, 4-hydroxy-3-(p-toluoyl)-6-(p-tolil)-2H-pyrane-2-one (DHT) and 5-bromo-4-hydroxy-3-(p-toluoyl)-6-(p-tolil)-2H-pyrane-2-one (BrDHT) concentrations higher than 12.0 M x L-1.When fungus was grown in broth, mould growth was reduced by 25% at a DHT concentration of 160 μ M x L-1, and aflatoxin B1 (AFB1) and aflatoxin G1 (AFG1) concentrations were reduced by 5% and 14%, respectively.In experiments with 2.5 and 25.0 μ M x L-1 of BrDHT, the maximum mould growth was 70% and 55% of that in the control broth.A 2.5 μ M x L-1 BrDHT concentration reduced the production of both investigated toxins to 92% and 85%, respectively.At 25.0 μ M of BrDHT, accumulation of AFB1 was 80% of that in control experiments, whereas the accumulation of AFG1 was 75% of the control value.In the media containing 125.0 μ M of BrDHT, the accumulation of aflatoxins was reduced to 45% and 60% of the control values.The growth of mould biomass was reduced by 35%.

Mycotoxins in Food; Aspergillus flavus; Aflatoxins B1 and G1; Biosynthesis; DHA; DHT; BrDHT

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